Literature summary for 2.3.1.286 extracted from

Langley, E.; Pearson, M.; Faretta, M.; Bauer, U.M.; Frye, R.A.; Minucci, S.; Pelicci, P.G.; Kouzarides, T.
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence (2002), EMBO J., 21, 2383-2396.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nuclear body	SIRT1 and p53 colocalize in nuclear bodies (punctate structures found in the nuclei of certain cells) upon upregulation of the promyelocytic leukemia protein	Homo sapiens	16604	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + [p53 protein]-N6-acetyl-L-lysine	Homo sapiens	SIRT1 deacetylase is a negative regulator of p53 function capable of modulating cellular senescence	nicotinamide + [p53 protein]-L-lysine + 2'-O-acetyl-ADP-ribose	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96EB6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + [p53 protein]-N6-acetyl-L-lysine	-	Homo sapiens	nicotinamide + [p53 protein]-L-lysine + 2'-O-acetyl-ADP-ribose	-	?
NAD+ + [p53 protein]-N6-acetyl-L-lysine	SIRT1 deacetylase is a negative regulator of p53 function capable of modulating cellular senescence	Homo sapiens	nicotinamide + [p53 protein]-L-lysine + 2'-O-acetyl-ADP-ribose	-	?

Synonyms

Synonyms	Comment	Organism
SIRT1	-	Homo sapiens

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Release 2023.1 (January 2023)