Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Streptomyces coelicolor |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces coelicolor | - |
- |
- |
Streptomyces coelicolor M145 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6 malonyl-CoA + 5 NADPH + NADH + 6 H+ | - |
Streptomyces coelicolor | (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CoA + 5 NADP+ + NAD+ + 6 CO2 + 4 H2O | - |
? | |
6 malonyl-CoA + 5 NADPH + NADH + 6 H+ | - |
Streptomyces coelicolor M145 | (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CoA + 5 NADP+ + NAD+ + 6 CO2 + 4 H2O | - |
? | |
additional information | the isolated subunit CpkC reduces octanoyl-CoA to octanal and further to 1-octanol in presence of NADH | Streptomyces coelicolor | ? | - |
? | |
additional information | the isolated subunit CpkC reduces octanoyl-CoA to octanal and further to 1-octanol in presence of NADH | Streptomyces coelicolor M145 | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | the C-terminal thioester reductase domain of the PKS and an omega-transaminase are responsible for release of the polyketide chain as an aldehyde and its subsequent reductive amination | Streptomyces coelicolor |