Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces coelicolor | Q9L8J0 | cluster gene, contains subunit genes cpkA, cpkB and cpkC | - |
Streptomyces coelicolor A3(2) | Q9L8J0 | cluster gene, contains subunit genes cpkA, cpkB and cpkC | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6 malonyl-CoA + 5 NADPH + NADH + 6 H+ | - |
Streptomyces coelicolor | (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CoA + 5 NADP+ + NAD+ + 6 CO2 + 4 H2O | - |
? | |
6 malonyl-CoA + 5 NADPH + NADH + 6 H+ | - |
Streptomyces coelicolor A3(2) | (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CoA + 5 NADP+ + NAD+ + 6 CO2 + 4 H2O | - |
? |
Organism | Comment | Expression |
---|---|---|
Streptomyces coelicolor | polyketide synthase is expressed in transition phase | additional information |
General Information | Comment | Organism |
---|---|---|
physiological function | the synthase consists of a loading module, five extension modules and a reductase as a terminal domain instead of a typical thioesterase. All acyltransferase domains are specific for a malonyl extender, and have a B-type ketoreductase. A gene disruption mutant does not exhibit any morphological, growth or antibiotic production (actinorhodin and undecyloprodigiosin) differences compared to the wild type, and no difference in antibacterial activity is observed as well as in the UV-Vis absorbance | Streptomyces coelicolor |