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Literature summary for 2.3.1.28 extracted from
- Characterization and comparison of chloramphenicol acetyltransferase variants (1979), Eur. J. Biochem., 100, 609-618.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,2'-dithiobis(pyridine) | - |
Clostridium perfringens |  |
| 2,2'-dithiobis(pyridine) | - |
Haemophilus influenzae | |
| 2,2'-dithiobis(pyridine) | - |
Proteus mirabilis | |
| 2,2'-dithiobis(pyridine) | - |
Streptococcus agalactiae | |
| 2,2'-dithiobis(pyridine) | - |
Streptomyces acrimycini | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0093 | - |
chloramphenicol | - |
Streptococcus agalactiae | |
| 0.01 | - |
chloramphenicol | - |
Streptococcus pneumoniae | |
| 0.0166 | - |
chloramphenicol | - |
Streptomyces acrimycini | |
| 0.0175 | - |
chloramphenicol | - |
Haemophilus parainfluenzae | |
| 0.0205 | - |
chloramphenicol | - |
Agrobacterium tumefaciens | |
| 0.0215 | - |
chloramphenicol | - |
Clostridium perfringens | |
| 0.031 | - |
chloramphenicol | - |
Proteus mirabilis | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 22500 | - |
x * 22500, SDS-PAGE | Streptococcus pneumoniae |
| 22500 | - |
x * 22500, SDS-PAGE | Proteus mirabilis |
| 22500 | - |
x * 22500, SDS-PAGE | Staphylococcus sp. |
| 22500 | - |
x * 22500, SDS-PAGE | Clostridium perfringens |
| 22500 | - |
x * 22500, SDS-PAGE | Streptococcus agalactiae |
| 22500 | - |
x * 22500, SDS-PAGE | Haemophilus parainfluenzae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Agrobacterium tumefaciens | - |
- |
- |
| Clostridium perfringens | - |
- |
- |
| Haemophilus influenzae | - |
- |
- |
| Haemophilus parainfluenzae | - |
- |
- |
| Proteus mirabilis | - |
- |
- |
| Staphylococcus sp. | - |
type A, type B and type C | - |
| Streptococcus agalactiae | - |
- |
- |
| Streptococcus pneumoniae | - |
- |
- |
| Streptomyces acrimycini | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + chloramphenicol | - |
Haemophilus influenzae | CoA + chloramphenicol 3-acetate | - |
? | |
| acetyl-CoA + chloramphenicol | - |
Streptococcus pneumoniae | CoA + chloramphenicol 3-acetate | - |
? | |
| acetyl-CoA + chloramphenicol | - |
Proteus mirabilis | CoA + chloramphenicol 3-acetate | - |
? | |
| acetyl-CoA + chloramphenicol | - |
Staphylococcus sp. | CoA + chloramphenicol 3-acetate | - |
? | |
| acetyl-CoA + chloramphenicol | - |
Agrobacterium tumefaciens | CoA + chloramphenicol 3-acetate | - |
? | |
| acetyl-CoA + chloramphenicol | - |
Clostridium perfringens | CoA + chloramphenicol 3-acetate | - |
? | |
| acetyl-CoA + chloramphenicol | - |
Streptococcus agalactiae | CoA + chloramphenicol 3-acetate | - |
? | |
| acetyl-CoA + chloramphenicol | - |
Haemophilus parainfluenzae | CoA + chloramphenicol 3-acetate | - |
? | |
| acetyl-CoA + chloramphenicol | - |
Streptomyces acrimycini | CoA + chloramphenicol 3-acetate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | - |
Haemophilus influenzae |
| ? | - |
Agrobacterium tumefaciens |
| ? | - |
Streptomyces acrimycini |
| ? | x * 22500, SDS-PAGE | Streptococcus pneumoniae |
| ? | x * 22500, SDS-PAGE | Proteus mirabilis |
| ? | x * 22500, SDS-PAGE | Staphylococcus sp. |
| ? | x * 22500, SDS-PAGE | Clostridium perfringens |
| ? | x * 22500, SDS-PAGE | Streptococcus agalactiae |
| ? | x * 22500, SDS-PAGE | Haemophilus parainfluenzae |
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