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Literature summary for 2.3.1.279 extracted from

  • Hatzios, S.K.; Schelle, M.W.; Holsclaw, C.M.; Behrens, C.R.; Botyanszki, Z.; Lin, F.L.; Carlson, B.L.; Kumar, P.; Leary, J.A.; Bertozzi, C.R.
    PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis (2009), J. Biol. Chem., 284, 12745-12751 .
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51809
-
mass spectrometry Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose Mycobacterium tuberculosis the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains a 2-(long-chain-fatty acyl)-trehalose + CoA
-
?
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose Mycobacterium tuberculosis H37Rv the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains a 2-(long-chain-fatty acyl)-trehalose + CoA
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WIK5
-
-
Mycobacterium tuberculosis H37Rv P9WIK5
-
-

Purification (Commentary)

Purification (Comment) Organism
expression in Escherichia coli BL21(DE3) Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains Mycobacterium tuberculosis a 2-(long-chain-fatty acyl)-trehalose + CoA
-
?
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278, mycolipenoyl-CoA-2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase) Mycobacterium tuberculosis a 2-(long-chain-fatty acyl)-trehalose + CoA
-
?
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains Mycobacterium tuberculosis H37Rv a 2-(long-chain-fatty acyl)-trehalose + CoA
-
?
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278, mycolipenoyl-CoA-2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase) Mycobacterium tuberculosis H37Rv a 2-(long-chain-fatty acyl)-trehalose + CoA
-
?

Synonyms

Synonyms Comment Organism
papA3
-
Mycobacterium tuberculosis

General Information

General Information Comment Organism
malfunction disruption of the papA3 gene from Mycobacterium tuberculosis results in the loss of polyacyltrehalose from bacterial lipid extracts Mycobacterium tuberculosis
metabolism the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains Mycobacterium tuberculosis