Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
51809 | - |
mass spectrometry | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose | Mycobacterium tuberculosis | the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains | a 2-(long-chain-fatty acyl)-trehalose + CoA | - |
? | |
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose | Mycobacterium tuberculosis H37Rv | the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains | a 2-(long-chain-fatty acyl)-trehalose + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WIK5 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WIK5 | - |
- |
Purification (Comment) | Organism |
---|---|
expression in Escherichia coli BL21(DE3) | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose | the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains | Mycobacterium tuberculosis | a 2-(long-chain-fatty acyl)-trehalose + CoA | - |
? | |
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose | the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278, mycolipenoyl-CoA-2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase) | Mycobacterium tuberculosis | a 2-(long-chain-fatty acyl)-trehalose + CoA | - |
? | |
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose | the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains | Mycobacterium tuberculosis H37Rv | a 2-(long-chain-fatty acyl)-trehalose + CoA | - |
? | |
a long-chain-fatty acyl-CoA + alpha,alpha-trehalose | the enzyme catalyses two successive activities. It first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278, mycolipenoyl-CoA-2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase) | Mycobacterium tuberculosis H37Rv | a 2-(long-chain-fatty acyl)-trehalose + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
papA3 | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
malfunction | disruption of the papA3 gene from Mycobacterium tuberculosis results in the loss of polyacyltrehalose from bacterial lipid extracts | Mycobacterium tuberculosis |
metabolism | the enzyme participates in the biosynthesis of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains | Mycobacterium tuberculosis |