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Literature summary for 2.3.1.275 extracted from

  • Lu, Y.; Zhang, Y.; Grimes, K.; Qi, J.; Lee, R.; Rock, C.
    Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens (2006), Mol. Cell., 23, 765-772 .
    View publication on PubMed
Search for more literature for 2.3.1.275

Application

Application Comment Organism
pharmacology the PlsX/Y pathway defines the most widely distributed pathway for the initiation of phospholipid formation in bacteria and represents a target for the development of antibacterial therapeutics Streptococcus pneumoniae

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptococcus pneumoniae

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane transmembrane protein with five membrane-spanning helices Streptococcus pneumoniae 16020
-

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae P0A4Q0
-
-
Streptococcus pneumoniae ATCC BAA-255 P0A4Q0
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged SpPlsY Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl phosphate + sn-glycerol 3-phosphate
-
 Streptococcus pneumoniae 1-palmitoyl-sn-glycerol 3-phosphate + phosphate
-
 ?
palmitoyl phosphate + sn-glycerol 3-phosphate
-
 Streptococcus pneumoniae ATCC BAA-255 1-palmitoyl-sn-glycerol 3-phosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
SpPlsY protein
-
 Streptococcus pneumoniae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Streptococcus pneumoniae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Streptococcus pneumoniae