Literature summary for 2.3.1.275 extracted from

Cherian, P.T.; Yao, J.; Leonardi, R.; Maddox, M.M.; Luna, V.A.; Rock, C.O.; Lee, R.E.
Acyl-sulfamates target the essential glycerol-phosphate acyltransferase (PlsY) in Gram-positive bacteria (2012), Bioorg. Med. Chem., 20, 4985-4994.

Search for more literature for 2.3.1.275

Inhibitors

Inhibitors	Comment	Organism	Structure
4-methoxyphenyl palmitoylsulfamate	good antimicrobial activity against both Staphylococcus aureus and Bacillus anthracis	Bacillus anthracis
4-methoxyphenyl palmitoylsulfamate	good antimicrobial activity against both Staphylococcus aureus and Bacillus anthracis	Staphylococcus aureus
4-methoxyphenyl undec-10-enoylsulfamate	broad antimicrobial profile with good activity against multiple species of Gram-positive bacteria	Bacillus anthracis
4-methoxyphenyl undec-10-enoylsulfamate	broad antimicrobial profile with good activity against multiple species of Gram-positive bacteria	Staphylococcus aureus
additional information	data suggest that acylsulfamate inhibitors may have off-target effects on bacterial membrane function	Bacillus anthracis
phenyl (8-phenyloctanoyl)sulfamate	good antimicrobial activity against both Staphylococcus aureus and Bacillus anthracis. Compound causes an abrupt cessation of cell growth and inhibits inhibits protein, DNA and RNA synthesis in Bacillus anthracis Sterne	Bacillus anthracis
phenyl (8-phenyloctanoyl)sulfamate	good antimicrobial activity against both Staphylococcus aureus and Bacillus anthracis. Staphylococcus aureus cell growth does not immediately cease following addition, but slows down over approximately 2 h before stopping completely. Compound causes a concentration dependent decrease in acetate incorporation into fatty acids and membrane phospholipids	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Bacillus anthracis	-	-	-
Staphylococcus aureus	-	-	-

Synonyms

Synonyms	Comment	Organism
PlsY	-	Staphylococcus aureus
PlsY1	-	Bacillus anthracis

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.008	-	pH 7.4, 37°C	Staphylococcus aureus	4-methoxyphenyl palmitoylsulfamate
0.025	-	pH 7.4, 37°C	Staphylococcus aureus	phenyl (8-phenyloctanoyl)sulfamate
0.027	-	pH 7.4, 37°C	Staphylococcus aureus	4-methoxyphenyl undec-10-enoylsulfamate

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Release 2023.1 (January 2023)