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Literature summary for 2.3.1.262 extracted from

  • Dulcey, C.E.; Dekimpe, V.; Fauvelle, D.A.; Milot, S.; Groleau, M.C.; Doucet, N.; Rahme, L.G.; Lepine, F.; Deziel, E.
    The end of an old hypothesis: the Pseudomonas signaling molecules 4-hydroxy-2-alkylquinolines derive from fatty acids, not 3-ketofatty acids (2013), Chem. Biol., 20, 1481-1491.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa P20582 cf. 2.3.1.230
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anthraniloyl-CoA + malonyl-CoA
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 Pseudomonas aeruginosa 2-aminobenzoylacetyl-CoA + CoA + CO2 overall reaction ?

General Information

General Information Comment Organism
physiological function 4-hydroxy-2-alkylquinolines biosynthesis requires the PqsABCD enzymes and proceeds by a two-step pathway: First, PqsD mediates the synthesis of 2-aminobenzoylacetate from anthraniloyl-CoA and malonyl-CoA, then the decarboxylating coupling of 2-aminobenzoylacetate to an octanoate group linked to PqsC produces 4-hydroxy-2-heptylquinoline, the direct precursor of Pseudomonas quinolone signal. PqsB is tightly associated with PqsC and required for the second step Pseudomonas aeruginosa