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Literature summary for 2.3.1.260 extracted from

  • Fu, H.; Ebert-Khosla, S.; Hopwood, D.; Khosla, C.
    Relaxed specificity of the oxytetracycline polyketide synthase for an acetate primer in the absence of a malonamyl primer (1994), J. Am. Chem. Soc., 116, 6443-6444.
No PubMed abstract available

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
malonamoyl-[OxyC acyl-carrier protein] + malonyl-CoA Streptomyces rimosus
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18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC acyl-carrier protein] + CO2 + CoA
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?

Organism

Organism UniProt Comment Textmining
Streptomyces rimosus
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
malonamoyl-[OxyC acyl-carrier protein] + malonyl-CoA
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Streptomyces rimosus 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC acyl-carrier protein] + CO2 + CoA
-
?
additional information the enzyme is intrinsically capable of synthesizing an acetate-derived polyketide backbone that is isosteric with the predicted polyketide backbone precursor of oxytetracycline Streptomyces rimosus ?
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?

Synonyms

Synonyms Comment Organism
otc PKS
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Streptomyces rimosus
oxytetracycline polyketide synthase
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Streptomyces rimosus