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Literature summary for 2.3.1.26 extracted from

  • Tomita, K.; Teratani, T.; Suzuki, T.; Shimizu, M.; Sato, H.; Narimatsu, K.; Usui, S.; Furuhashi, H.; Kimura, A.; Nishiyama, K.; Maejima, T.; Okada, Y.; Kurihara, C.; Shimamura, K.; Ebinuma, H.; Saito, H.; Yokoyama, H.; Watanabe, C.; Komoto, S.; Nagao, S.; Sugiyama, K.; Aosasa, S.; Hatsuse, K.; Yamamoto, J.; Hibi, T.; Miura, S.; Hokari, R.; Kanai, T.
    Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells (2014), J. Hepatol., 61, 98-106.
    View publication on PubMed
Search for more literature for 2.3.1.26

Application

Application Comment Organism
drug development regulation of ACAT1 activities in hepatic stellate cells can be a target for treatment of liver fibrosis Homo sapiens
drug development regulation of ACAT1 activities in hepatic stellate cells can be a target for treatment of liver fibrosis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + cholesterol Homo sapiens
-
 CoA + cholesterol ester
-
 ?
acyl-CoA + cholesterol Mus musculus
-
 CoA + cholesterol ester
-
 ?
acyl-CoA + cholesterol Mus musculus C57BL/6
-
 CoA + cholesterol ester
-
 ?
oleoyl-CoA + cholesterol Homo sapiens
-
 CoA + cholesterol oleate
-
 ?
oleoyl-CoA + cholesterol Mus musculus
-
 CoA + cholesterol oleate
-
 ?
oleoyl-CoA + cholesterol Mus musculus C57BL/6
-
 CoA + cholesterol oleate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P35610
-
-
Mus musculus Q61263
-
-
Mus musculus C57BL/6 Q61263
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatic stellate cell
-
 Mus musculus
-
hepatic stellate cell isozyme ACAT1 is the major isozyme in human primary hepatic stellate cells, little isozyme ACAT2 expression in the cells Homo sapiens
-
hepatocyte primary Homo sapiens
-
hepatocyte primary Mus musculus
-
Kupffer cell
-
 Homo sapiens
-
Kupffer cell
-
 Mus musculus
-
liver
-
 Homo sapiens
-
liver
-
 Mus musculus
-
additional information ACAT1 is the major isozyme in mouse primary hepatic stellate cells, and ACAT2 is the major isozyme in mouse primary hepatocytes and Kupffer cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol ester
-
 ?
acyl-CoA + cholesterol
-
 Mus musculus CoA + cholesterol ester
-
 ?
acyl-CoA + cholesterol
-
 Mus musculus C57BL/6 CoA + cholesterol ester
-
 ?
oleoyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol oleate
-
 ?
oleoyl-CoA + cholesterol
-
 Mus musculus CoA + cholesterol oleate
-
 ?
oleoyl-CoA + cholesterol
-
 Mus musculus C57BL/6 CoA + cholesterol oleate
-
 ?

Synonyms

Synonyms Comment Organism
ACAT1
-
 Homo sapiens
ACAT1
-
 Mus musculus
acyl-CoA:cholesterol acyltransferase 1
-
 Homo sapiens
acyl-CoA:cholesterol acyltransferase 1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction ACAT1 deficiency significantly increases free cholesterol levels in hepatic stellate cells, augmenting Toll-like receptor 4, TLR4, protein and downregulating expression of transforming growth factor-beta (TGFbeta) pseudoreceptor Bambi (bone morphogenetic protein and activin membrane-bound inhibitor), leading to sensitization of hepatic stellate cells to TGFbeta activation. Exacerbation of liver fibrosis by ACAT1 deficiency is dependent on free cholesterol accumulation-induced enhancement of TLR4 signaling, effects of ACAT1 deficiency on induced liver fibrosis, overview. ACAT1 deficiency does not affect hepatocellular damage Mus musculus
malfunction ACAT1 deficiency significantly increases free cholesterol levels in hepatic stellate cells, augmenting Toll-like receptor 4, TLR4, protein and downregulating expression of transforming growth factor-beta (TGFbeta) pseudoreceptor Bambi (bone morphogenetic protein and activin membrane-bound inhibitor), leading to sensitization of hepatic stellate cells to TGFbeta activation. Exacerbation of liver fibrosis by ACAT1 deficiency is dependent on free cholesterol accumulation-induced enhancement of TLR4 signaling. ACAT1 deficiency does not affect hepatic ACAT2 expression, effects of ACAT1 deficiency on induced liver fibrosis, overview Homo sapiens
physiological function acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells, role of ACAT1 in the pathogenesis of liver fibrosis, overview Homo sapiens
physiological function acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells, role of ACAT1 in the pathogenesis of liver fibrosis, overview Mus musculus