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Literature summary for 2.3.1.26 extracted from

  • Hu, H.; Liao, H.; Zhang, J.; Wu, W.; Yan, J.; Yan, Y.; Zhao, Q.; Zou, Y.; Chai, X.; Yu, S.; Wu, Q.
    First identification of xanthone sulfonamides as potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors (2010), Bioorg. Med. Chem. Lett., 20, 3094-3097.
    View publication on PubMed
Search for more literature for 2.3.1.26

Inhibitors

Inhibitors Comment Organism Structure
2,3,6,8-tetramethoxy-5-(piperidin-1-ylsulfonyl)-1,4-dihydro-9H-xanthen-9-one 10 microgram/ml, 10.53% inhibition Homo sapiens
2,3,6,8-tetramethoxy-5-[(4-phenyl-3,6-dihydropyridin-1(2H)-yl)sulfonyl]-1,4-dihydro-9H-xanthen-9-one 10 microgram/ml, 51.34% inhibition Homo sapiens
2,3,6,8-tetramethoxy-5-{[4-(3-methylphenyl)piperazin-1-yl]sulfonyl}-1,4-dihydro-9H-xanthen-9-one 10 microgram/ml, 64.8% inhibition Homo sapiens
2,3,6,8-tetramethoxy-5-{[4-(4-methoxyphenyl)piperazin-1-yl]sulfonyl}-1,4-dihydro-9H-xanthen-9-one 10 microgram/ml, 36.92% inhibition Homo sapiens
2,3,6,8-tetramethoxy-5-{[4-(pyridin-2-yl)piperazin-1-yl]sulfonyl}-1,4-dihydro-9H-xanthen-9-one 10 microgram/ml, 43.56% inhibition Homo sapiens
2,3,6,8-tetramethoxy-9-oxo-N-(2-phenylpropyl)-4,9-dihydro-1H-xanthene-5-sulfonamide 10 microgram/ml, 10.78% inhibition Homo sapiens
2,3,6,8-tetramethoxy-N-(naphthalen-2-ylmethyl)-9-oxo-4,9-dihydro-1H-xanthene-5-sulfonamide 10 microgram/ml, 25% inhibition Homo sapiens
5-[(4-aminopiperazin-1-yl)sulfonyl]-2,3,6,8-tetramethoxy-1,4-dihydro-9H-xanthen-9-one 10 microgram/ml, 14.5% inhibition Homo sapiens
5-{[(2R,6S)-2,6-dimethylmorpholin-4-yl]sulfonyl}-2,3,6,8-tetramethoxy-1,4-dihydro-9H-xanthen-9-one 10 microgram/ml, 8.84% inhibition Homo sapiens
5-{[3-(dimethylamino)pyrrolidin-1-yl]sulfonyl}-2,3,6,8-tetramethoxy-1,4-dihydro-9H-xanthen-9-one 10 microgram/ml, 20.96% inhibition Homo sapiens
ethyl 1-[(2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthen-5-yl)sulfonyl]piperidine-3-carboxylate 10 microgram/ml, 7.99% inhibition Homo sapiens
ethyl N-methyl-N-[(2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthen-5-yl)sulfonyl]glycinate 10 microgram/ml, 16.79% inhibition Homo sapiens
methyl N-[(2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthen-5-yl)sulfonyl]glycinate 10 microgram/ml, 5.13% inhibition Homo sapiens
N,N-diethyl-1-[(2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthen-5-yl)sulfonyl]piperidine-3-carboxamide 10 microgram/ml, 12.59% inhibition Homo sapiens
N-(3-chlorobenzyl)-2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthene-5-sulfonamide 10 microgram/ml, 15.76% inhibition Homo sapiens
N-(4-fluorobenzyl)-2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthene-5-sulfonamide 10 microgram/ml, 10.24% inhibition Homo sapiens
N-(benzyloxy)-2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthene-5-sulfonamide 10 microgram/ml, 16.76% inhibition Homo sapiens
N-[2-(3,4-dimethylphenyl)ethyl]-2,3,6,8-tetramethoxy-9-oxo-4,9-dihydro-1H-xanthene-5-sulfonamide 10 microgram/ml, 11.86% inhibition Homo sapiens
N-[3-(3,4-dimethoxyphenyl)propyl]-2,3,6,8-tetramethoxy-N-methyl-9-oxo-4,9-dihydro-1H-xanthene-5-sulfonamide 10 microgram/ml, 30.06% inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
ACAT
-
 Homo sapiens