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Literature summary for 2.3.1.26 extracted from

  • He, P.; Cheng, B.; Wang, Y.; Wang, H.
    Effect of tumor necrosis factor-alpha on acyl coenzyme A: cholesteryl acyltransferase activity and ACAT1 gene expression in THP-1 macrophages (2007), J. Huazhong Univ. Sci. Technol. Med. Sci., 27, 170-172.
    View publication on PubMed
Search for more literature for 2.3.1.26

Activating Compound

Activating Compound Comment Organism Structure
TNF-alpha up-regulating of ACAT1 expression Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + cholesterol Homo sapiens
-
 CoA + cholesterol ester
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
THP-1 cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00561
-
 TNFalpha treatment, duration 1 h Homo sapiens
0.00562
-
 TNFalpha treatment, duration 0 h Homo sapiens
0.00562
-
 TNFalpha treatment, duration 0.5 h Homo sapiens
0.00842
-
 TNFalpha treatment, duration 2 h Homo sapiens
0.00868
-
 TNFalpha treatment, duration 6 h Homo sapiens
0.0102
-
 TNFalpha treatment, duration 12 h Homo sapiens
0.01121
-
 TNFalpha treatment, duration 24 h Homo sapiens
0.02041
-
 TNFalpha treatment, duration 48 h Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol ester
-
 ?
oleoyl-CoA + cholesterol ACAT activity assay Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ACAT1
-
 Homo sapiens
acyl coenzyme A: cholesteryl acyltransferase
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 activity assay Homo sapiens