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Literature summary for 2.3.1.26 extracted from

  • Pramfalk, C.; Angelin, B.; Eriksson, M.; Parini, P.
    Cholesterol regulates ACAT2 gene expression and enzyme activity in human hepatoma cells (2007), Biochem. Biophys. Res. Commun., 364, 402-409.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cholesterol ACAT2 is transcriptionally regulated by cholesterol Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Homo sapiens 16020
-
rough endoplasmic reticulum
-
Homo sapiens 5791
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + cholesterol Homo sapiens
-
CoA + cholesterol ester
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
microsomes are prepared Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
enterocyte
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
hepatocyte
-
Homo sapiens
-
hepatoma cell
-
Homo sapiens
-
Huh-7 cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0127
-
ACAT2 activity in HuH-7 cells, control Homo sapiens
0.0192
-
ACAT2 activity in HuH-7 cells, 30 microM HDL cholesterol Homo sapiens
0.0347
-
ACAT2 activity in HuH-7 cells, 0.5 mM LDL cholesterol Homo sapiens
0.039
-
ACAT2 activity in HuH-7 cells, control Homo sapiens
0.0558
-
ACAT1 activity in HuH-7 cells, control Homo sapiens
0.0701
-
ACAT1 activity in HuH-7 cells, 0.5 mM LDL cholesterol Homo sapiens
0.086
-
ACAT1 activity in HuH-7 cells, control Homo sapiens
0.0946
-
ACAT2 activity in HuH-7 cells, 0.1 mM free cholesterol Homo sapiens
0.1102
-
ACAT1 activity in HuH-7 cells, 0.1 mM free cholesterol Homo sapiens
0.1861
-
ACAT1 activity in HuH-7 cells, 30 microM HDL cholesterol Homo sapiens
2210
-
ACAT2 activity in Hep-G2 cells, control Homo sapiens
3220
-
ACAT2 activity in Hep-G2 cells, control Homo sapiens
4650
-
ACAT1 activity in Hep-G2 cells, 1.5 mM LDL cholesterol Homo sapiens
4730
-
ACAT1 activity in Hep-G2 cells, 1 mM HDL cholesterol Homo sapiens
4980
-
ACAT1 activity in Hep-G2 cells, control Homo sapiens
5030
-
ACAT2 activity in Hep-G2 cells, 1.5 mM LDL cholesterol Homo sapiens
5750
-
ACAT1 activity in Hep-G2 cells, control Homo sapiens
5810
-
ACAT1 activity in Hep-G2 cells, 0.9 mM free cholesterol Homo sapiens
6230
-
ACAT2 activity in Hep-G2 cells, 1 mM HDL cholesterol Homo sapiens
9560
-
ACAT2 activity in Hep-G2 cells, 0.9 mM free cholesterol Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + cholesterol
-
Homo sapiens CoA + cholesterol ester
-
?

Synonyms

Synonyms Comment Organism
ACAT1
-
Homo sapiens
ACAT2
-
Homo sapiens
acyl-coenzyme A:cholesterol acyltransferase
-
Homo sapiens
Soat1
-
Homo sapiens
Soat2
-
Homo sapiens
steroyl O-acyltransferase 1
-
Homo sapiens
steroyl O-acyltransferase 2
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
activity assay Homo sapiens