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Literature summary for 2.3.1.26 extracted from
- Cholesterol synthesis inhibition elicits an integrated molecular response in human livers including decreased ACAT2 (2008), Arterioscler. Thromb. Vasc. Biol., 28, 1200-1206.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | statin treatment reduces ACAT2 activity in human liver and this effect, in combination with a reduced ApoE expression, may contribute to the favorable lowering of VLDL cholesterol seen in addition to the LDL lowering during statin treatment | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
determined by SDS-PAGE and Western Blot analysis | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + cholesterol | Homo sapiens | - |
CoA + cholesterol ester | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0000293 | - |
ACAT2 activity, effect on ChSI on hepatic ACAT2 expression, high cholesterol synthesis inhibition, high ChSI | Homo sapiens |
| 0.0000333 | - |
ACAT2 activity, effect on ChSI on hepatic ACAT2 expression, low cholesterol synthesis inhibition, low ChSI | Homo sapiens |
| 0.0000377 | - |
ACAT2 activity, effect on cholesterol synthesis inhibition on hepatic ACAT2 expression, placebo | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + cholesterol | - |
Homo sapiens | CoA + cholesterol ester | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACAT2 | - |
Homo sapiens |
| acyl-CoA:cholesterol acyltransferase 2 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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