Literature summary for 2.3.1.26 extracted from

Gelain, A.; Bettinelli, I.; Barlocco, D.; Kwon, B.M.; Jeong, T.S.; Cho, K.H.; Toma, L.
Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors (2005), J. Med. Chem., 48, 7708-7713.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3-(2,4-difluorophenyl)-1-heptyl-1-[5-[(5-phenylpyridazin-3-yl)amino]pentyl]urea	0.05 mg/ml, 46% inhibition	Rattus norvegicus
3-(2,4-difluorophenyl)-1-heptyl-1-[5-[(5-phenylpyridazin-3-yl)sulfanyl]pentyl]urea	0.05 mg/ml, 75% inhibition	Rattus norvegicus
3-(2,4-difluorophenyl)-1-heptyl-1-[5-[(5-phenylpyridazin-3-yl)sulfinyl]pentyl]urea	0.05 mg/ml, 62% inhibition	Rattus norvegicus
3-(2,4-difluorophenyl)-1-heptyl-1-[5-[(5-phenylpyridazin-3-yl)sulfonyl]pentyl]urea	0.05 mg/ml, 67% inhibition	Rattus norvegicus
3-(2,4-difluorophenyl)-1-heptyl-1-[5-[(6-phenylpyridazin-3-yl)amino]pentyl]urea	0.05 mg/ml, 89% inhibition	Rattus norvegicus
3-(2,4-difluorophenyl)-1-heptyl-1-[5-[(6-phenylpyridazin-3-yl)sulfinyl]pentyl]urea	0.05 mg/ml, 55% inhibition	Rattus norvegicus
3-(2,4-difluorophenyl)-1-heptyl-1-[5-[(6-phenylpyridazin-3-yl)sulfonyl]pentyl]urea	0.05 mg/ml, 43% inhibition	Rattus norvegicus
3-(2,4-difluorophenyl)-1-octyl-1-[5-[(6-phenylpyridazin-3-yl)sulfanyl]pentyl]urea	0.05 mg/ml, 44% inhibition	Rattus norvegicus
3-(2,4-difluorophenyl)-1-[5-[(5,6-diphenylpyridazin-3-yl)amino]pentyl]-1-heptylurea	0.05 mg/ml, 87% inhibition	Rattus norvegicus
3-(2,4-difluorophenyl)-1-[5-[(5,6-diphenylpyridazin-3-yl)sulfanyl]pentyl]-1-heptylurea	0.05 mg/ml, 75% inhibition	Rattus norvegicus
3-(2,4-difluorophenyl)-1-[5-[(5,6-diphenylpyridazin-3-yl)sulfinyl]pentyl]-1-heptylurea	0.05 mg/ml, 65% inhibition	Rattus norvegicus
3-(2,4-difluorophenyl)-1-[5-[(5,6-diphenylpyridazin-3-yl)sulfonyl]pentyl]-1-heptylurea	0.05 mg/ml, 70% inhibition	Rattus norvegicus
GERIBP001M	0.05 mM, 83% inhibition	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Synonyms

Synonyms	Comment	Organism
ACAT	-	Rattus norvegicus

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Release 2023.1 (January 2023)