Literature summary for 2.3.1.26 extracted from

Im, K.R.; Jeong, T.S.; Kwon, B.M.; Baek, N.I.; Kim, S.H.; Kim, D.K.
Acyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda (2006), Arch. Pharm. Res., 29, 191-194.

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Inhibitors

Inhibitors	Comment	Organism	Structure
betulin	IC50: 0.083 mM, hACAT-1	Homo sapiens
lupeol	IC50: 0.048 mM, hACAT-1	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O75908	-	-
Homo sapiens	P35610	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
oleoyl-CoA + cholesterol	-	Homo sapiens	CoA + cholesteryl oleate	-	?

Synonyms

Synonyms	Comment	Organism
hACAT-1	-	Homo sapiens
hACAT-2	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.048	-	IC50: 0.048 mM, hACAT-1	Homo sapiens	lupeol
0.083	-	IC50: 0.083 mM, hACAT-1	Homo sapiens	betulin

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Release 2023.1 (January 2023)