Literature summary for 2.3.1.26 extracted from

Liang, J.J.; Oelkers, P.; Guo, C.; Chu, P.C.; Dixon, J.L.; Ginsberg, H.N.; Sturley, S.L.
Overexpression of human diacylglycerol acyltransferase 1, acyl-coa:cholesterol acyltransferase 1, or acyl-CoA:cholesterol acyltransferase 2 stimulates secretion of apolipoprotein B-containing lipoproteins in McA-RH7777 cells (2004), J. Biol. Chem., 279, 44938-44944.

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Application

Application	Comment	Organism
medicine	for both isoform ACTA1 and ACAT2, overexpression in rat hepatoma McA-RH7777 cells results in increased synthesis, cellular accumulation, and secretion of cholesteryl esters. This leads to decreased intracellular degradation and increased secretion of very low density liporotein apoB. Overexpression of ACAT2 has significantly greater impact upon assembly and secretion of very low density liporotein from liver cells than that of ACAT1	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoforms ACTA1 and ACAT2, overexpression in rat hepatoma McA-RH7777 cells	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)