Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cholesterol | presence of cholesterol stimulates reaction of ACAT1 with sitosterol up to 3fold, reaction of ACAT2 is only moderately activated | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
recombinant isoforms ACAT1 and ACAT2 with His-tag each | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | stereochemistry of 3-hydroxyl group at steroid ring is a critical structural feature for ACAT1 isoform | Homo sapiens | ? | - |
? | |
oleoyl-CoA + cholesterol | - |
Homo sapiens | CoA + cholesteryl oleate | - |
? | |
oleoyl-CoA + sitosterol | - |
Homo sapiens | CoA + sitosteryl oleate | - |
? |