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Literature summary for 2.3.1.26 extracted from

  • Kerkhoff, C.; Beuck, M.; Threige-Rasmussen, J.; Spener, F.; Knudsen, J.; Schmitz, G.
    Acyl-CoA binding protein (ACBP) regulates acyl-CoA:cholesterol acyltransferase (ACAT) in human mononuclear phagocytes (1997), Biochim. Biophys. Acta, 1346, 163-172.
    View publication on PubMed
Search for more literature for 2.3.1.26

Activating Compound

Activating Compound Comment Organism Structure
liver fatty acid binding protein/bovine serum albumin small increase in activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
acyl-CoA binding protein 3fold decrease in activity Homo sapiens
acyl-CoA binding protein/oleoyl-CoA complexes strongly inhibit Homo sapiens
diazepam competes with oleoyl-CoA for its binding to microsomal membranes Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
 oleoyl-CoA bound to acyl-CoA binding protein Homo sapiens
0.03
-
 oleoyl-CoA in the absence of acyl-CoA binding protein Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mononuclear phagocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000053 0.000008
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme activity is regulated by the acyl-CoA binding protein ACBP Homo sapiens ?
-
 ?
oleoyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesteryl oleate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens