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Literature summary for 2.3.1.26 extracted from

  • Simpson, E.R.; Burkhart, M.F.
    Acyl CoA:cholesterol acyl transferase activity in human placental microsomes: inhibition by progesterone (1980), Arch. Biochem. Biophys., 200, 79-85.
    View publication on PubMed
Search for more literature for 2.3.1.26

Activating Compound

Activating Compound Comment Organism Structure
ATP slight stimulation Homo sapiens
cholesterol exogenous, not stimulatory Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
17alpha-hydroxyprogesterone
-
 Homo sapiens
5alpha-dihydroprogesterone
-
 Homo sapiens
androstenedione
-
 Homo sapiens
dehydroisoandrosterone
-
 Homo sapiens
deoxycorticosterone
-
 Homo sapiens
estradiol-17beta
-
 Homo sapiens
additional information corticosterone, cortisol and estriol have little effect, enzyme activity in placenta may be regulated by endogenously synthesized steroid hormones Homo sapiens
pregnenolone
-
 Homo sapiens
progesterone 50% inhibition at 0.02 mM Homo sapiens
testosterone
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.038
-
 oleoyl-CoA
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol ester
-
 ?
additional information oleic acid is not incorporated into cholesterol esters by placental microsomes even in the presence of ATP, CoA and MgCl2 Homo sapiens ?
-
 ?
oleoyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesteryl oleate
-
 ?

Cofactor

Cofactor Comment Organism Structure
CoA
-
 Homo sapiens