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Literature summary for 2.3.1.259 extracted from

  • Van Damme, P.; Hole, K.; Pimenta-Marques, A.; Helsens, K.; Vandekerckhove, J.; Martinho, R.G.; Gevaert, K.; Arnesen, T.
    NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation (2011), PLoS Genet., 7, e1002169.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.259

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 Star cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H7X0
-
-

Purification (Commentary)

Purification (Comment) Organism
HisTrap column chromatography and Superdex 75 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + MAPLDLDRWGRPVGRRRRPVRVYP
-
 Homo sapiens Nalpha-acetyl-MAPLDLDRWGRPVGRRRRPVRVYP + CoA
-
 ?
acetyl-CoA + MDELFPLRWGRPVGRRRRPVRVYP
-
 Homo sapiens Nalpha-acetyl-MDELFPLRWGRPVGRRRRPVRVYP + CoA
-
 ?
acetyl-CoA + MKKSYSGRWGRPVGRRRRPVRVYP
-
 Homo sapiens Nalpha-acetyl-MKKSYSGRWGRPVGRRRRPVRVYP + CoA
-
 ?
acetyl-CoA + MLGPEGGRWGRPVGRRRRPVRVYP second highest N-terminal acetylation activity Homo sapiens Nalpha-acetyl-MLGPEGGRWGRPVGRRRRPVRVYP + CoA
-
 ?
acetyl-CoA + MLGTEGGRWGRPVGRRRRPVRVYP highest N-terminal acetylation activity Homo sapiens Nalpha-acetyl-MLGTEGGRWGRPVGRRRRPVRVYP + CoA
-
 ?
additional information almost no activity with peptides SESSSKSRWGRPVGRRRRPVRVYP and SYSMDHFRWGRPVGRRRRPVRVYP Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Naa60p
-
 Homo sapiens
NatF
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme is important for normal chromosome segregation Homo sapiens