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Literature summary for 2.3.1.258 extracted from

  • Hou, F.; Chu, C.; Kong, X.; Yokomori, K.; Zou, H.
    The acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner (2007), J. Cell Biol., 177, 587-597.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.258

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
Y124F the mutant shows decreased activity compared to the wild type enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
19000
-
 x * 19000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9GZZ1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 19000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
SAN
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme depletion causes premature sister chromatid separation in HeLa cells Homo sapiens
physiological function the acetyltransferase activity of San stabilizes the mitotic cohesin at the centromeres in a shugoshin-independent manner. The enzyme is specifically required for the maintenance of the centromeric cohesion in mitosis Homo sapiens