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Literature summary for 2.3.1.258 extracted from

  • Evjenth, R.; Hole, K.; Karlsen, O.; Ziegler, M.; Amesen, T.; Lillehaug, J.
    Human Naa50p (Nat5/San) displays both protein Nalpha- and Nepsilon-acetyltransferase activity (2009), J. Biol. Chem., 284, 31122-31129.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.258

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0069
-
 acetyl-CoA at pH 8.5 and 37°C Homo sapiens
0.079
-
 MLGPERRR at pH 8.5 and 37°C Homo sapiens
0.091
-
 MLDPERRR at pH 8.5 and 37°C Homo sapiens
0.185
-
 MIGPERRR at pH 8.5 and 37°C Homo sapiens
0.19
-
 MLALIRRR at pH 8.5 and 37°C Homo sapiens
0.32
-
 MLGTGRRR at pH 8.5 and 37°C Homo sapiens
0.416
-
 MLGTERRR at pH 8.5 and 37°C Homo sapiens
0.46
-
 MLRPERRR at pH 8.5 and 37°C Homo sapiens
0.478
-
 MLLPERRR at pH 8.5 and 37°C Homo sapiens
3.734
-
 MFGPERRR at pH 8.5 and 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9GZZ1
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + MDELFRRR
-
 Homo sapiens Nalpha-acetyl-MDELFRRR + CoA
-
 ?
acetyl-CoA + MFGPERRR
-
 Homo sapiens Nalpha-acetyl-MFGPERRR + CoA
-
 ?
acetyl-CoA + MIGPERRR
-
 Homo sapiens Nalpha-acetyl-MIGPERRR + CoA
-
 ?
acetyl-CoA + MKEEVRRR
-
 Homo sapiens Nalpha-acetyl-MKEEVRRR + CoA
-
 ?
acetyl-CoA + MLALIRRR
-
 Homo sapiens Nalpha-acetyl-MLALIRRR + CoA
-
 ?
acetyl-CoA + MLDPERRR
-
 Homo sapiens Nalpha-acetyl-MLDPERRR + CoA
-
 ?
acetyl-CoA + MLGPERRR best substrate Homo sapiens Nalpha-acetyl-MLGPERRR + CoA
-
 ?
acetyl-CoA + MLGTERRR
-
 Homo sapiens Nalpha-acetyl-MLGTERRR + CoA
-
 ?
acetyl-CoA + MLGTGRRR
-
 Homo sapiens Nalpha-acetyl-MLGTGRRR + CoA
-
 ?
acetyl-CoA + MLLPERRR
-
 Homo sapiens Nalpha-acetyl-MLLPERRR + CoA
-
 ?
acetyl-CoA + MLRPERRR
-
 Homo sapiens Nalpha-acetyl-MLRPERRR + CoA
-
 ?
additional information Naa50p (Nat5/San) displays both protein Nalpha- and Nepsilon-acetyltransferase activity Homo sapiens ?
-
 ?
additional information no activity with peptides SESSRRR, SYSMRRR, and DDIARRR Homo sapiens ?
-
 ?
additional information preferably the enzyme acetylates oligopeptides with N-termini Met-Leu-Xxx-Pro. Furthermore, the enzyme autoacetylates lysines 34, 37, and 140 in vitro as well as histone 4 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Naa50p
-
 Homo sapiens
NAT5/SAN
-
 Homo sapiens
NatA subunit of NatA Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.04
-
 MLGTGRRR at pH 8.5 and 37°C Homo sapiens
0.09
-
 MLGTERRR at pH 8.5 and 37°C Homo sapiens
0.11
-
 MLALIRRR at pH 8.5 and 37°C Homo sapiens
0.12
-
 MLGPERRR at pH 8.5 and 37°C Homo sapiens
0.12
-
 MLDPERRR at pH 8.5 and 37°C Homo sapiens
0.18
-
 MIGPERRR at pH 8.5 and 37°C Homo sapiens