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Literature summary for 2.3.1.257 extracted from

  • Song, O.k.; Wang, X.; Waterborg, J.H.; Sternglanz, R.
    An Nalpha-acetyltransferase responsible for acetylation of the N-terminal residues of histones H4 and H2A (2003), J. Biol. Chem., 278, 38109-38112.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + an N-terminal-L-seryl-[histone H2A] Saccharomyces cerevisiae
-
an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
-
?
acetyl-CoA + an N-terminal-L-seryl-[histone H4] Saccharomyces cerevisiae
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an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni2+-affinity column chromatography, and Superdex 200 gel filtration Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + an N-terminal-L-seryl-[histone H2A]
-
Saccharomyces cerevisiae an N-terminal-Nalpha-acetyl-L-seryl-[histone H2A] + CoA
-
?
acetyl-CoA + an N-terminal-L-seryl-[histone H4]
-
Saccharomyces cerevisiae an N-terminal-Nalpha-acetyl-L-seryl-[histone H4] + CoA
-
?
additional information does not acetylate histone H3 or adrenocorticotropin Saccharomyces cerevisiae ?
-
?

Synonyms

Synonyms Comment Organism
NAT4
-
Saccharomyces cerevisiae
NatD
-
Saccharomyces cerevisiae