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Literature summary for 2.3.1.255 extracted from

  • Doerfel, M.J.; Lyon, G.J.
    The biological functions of Naa10 - From amino-terminal acetylation to human disease (2015), Gene, 567, 103-131.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.255

Application

Application Comment Organism
medicine the enzyme is associated with Ogden syndrome Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26000
-
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P41227
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
HT-1080 cell
-
 Homo sapiens
-
U2OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Naa10 undergoes autoacetylation at lysine K136 Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 26000, calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
ARD1
-
 Homo sapiens
arrest-defective protein 1 homologue
-
 Homo sapiens
DXS707
-
 Homo sapiens
NAA10 gene name, catalytic subunit of NatA Homo sapiens
Nalpha-acetyltransferase 10
-
 Homo sapiens
NatA
-
 Homo sapiens
TE2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the expression of Naa10 increases during neuronal dendritic development of cerebellar Purkinje cells up

General Information

General Information Comment Organism
malfunction knockdown of Naa10 in HeLa cells leads to apoptosis and sensitizes cells for daunorubicin-induced apoptosis Homo sapiens
metabolism Naa10 activates and/or amplifies the transcriptional activity of beta-catenin/TCF transcriptional activity thereby stimulating cyclin D1 and c-Myc expression leading to inhibition of p21WAF1/CIP1 and promoting the G1/S cell cycle transition. Naa10 is essential for the activation of caspase-2/-3/-7 and -9 in HeLa cells after doxorubicin stimulation Homo sapiens