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Literature summary for 2.3.1.251 extracted from

  • Preston, A.; Maxim, E.; Toland, E.; Pishko, E.J.; Harvill, E.T.; Caroff, M.; Maskell, D.J.
    Bordetella bronchiseptica PagP is a Bvg-regulated lipid A palmitoyl transferase that is required for persistent colonization of the mouse respiratory tract (2003), Mol. Microbiol., 48, 725-736.
    View publication on PubMed
Search for more literature for 2.3.1.251

Application

Application Comment Organism
medicine PagP is not required for the initial colonization of the mouse respiratory tract by Bordetella bronchiseptica, but is required for persistence of the organism within this organ Bordetella bronchiseptica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A Bordetella bronchiseptica
-
 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A Bordetella bronchiseptica ATCC BAA-588
-
 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
additional information Bordetella bronchiseptica enzyme from Bordetella bronchiseptica transfers palmitates to the lipid A C-3' positions ?
-
 ?
additional information Bordetella bronchiseptica ATCC BAA-588 enzyme from Bordetella bronchiseptica transfers palmitates to the lipid A C-3' positions ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bordetella bronchiseptica Q7WFT9
-
-
Bordetella bronchiseptica ATCC BAA-588 Q7WFT9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
-
 Bordetella bronchiseptica 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
-
 Bordetella bronchiseptica ATCC BAA-588 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
additional information enzyme from Bordetella bronchiseptica transfers palmitates to the lipid A C-3' positions Bordetella bronchiseptica ?
-
 ?
additional information enzyme from Bordetella bronchiseptica transfers palmitates to the lipid A C-3' positions Bordetella bronchiseptica ATCC BAA-588 ?
-
 ?

General Information

General Information Comment Organism
physiological function lipid A of a PagP mutant differs from wild-type lipid A by the absence of a palmitate group in secondary acylation at the C3' position. PagP mediates modification of the lipid A as part of the overall Bvg-mediated adaptation of this organism to changing environmental conditions. PagP is not required for the initial colonization of the mouse respiratory tract by Bordetella bronchiseptica, but is required for persistence of the organism within this organ Bordetella bronchiseptica