Literature summary for 2.3.1.244 extracted from

Meehan, M.J.; Xie, X.; Zhao, X.; Xu, W.; Tang, Y.; Dorrestein, P.C.
FT-ICR-MS characterization of intermediates in the biosynthesis of the alpha-methylbutyrate side chain of lovastatin by the 277 kDa polyketide synthase LovF (2011), Biochemistry, 50, 287-299.

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Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
277000	-	-	Aspergillus terreus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine	Aspergillus terreus	the enzyme is involved in the lovastatin biosynthetic pathway	(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Aspergillus terreus	Q9Y7D5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine	the enzyme is involved in the lovastatin biosynthetic pathway	Aspergillus terreus	(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O	-	?
acetyl-CoA + malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine	the overall reaction comprises a single condensation reaction followed by alpha-methylation, beta-ketoreduction, dehydration, and alpha,beta enoyl reduction	Aspergillus terreus	(S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O	-	?

Subunits

Subunits	Comment	Organism
?	277000, calculated from sequence	Aspergillus terreus

Synonyms

Synonyms	Comment	Organism
LocF	-	Aspergillus terreus

Cofactor

Cofactor	Comment	Organism	Structure
4'-phosphopantetheine	covalently bound	Aspergillus terreus

General Information

General Information	Comment	Organism
metabolism	the enzyme is involved in the lovastatin biosynthetic pathway	Aspergillus terreus

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Release 2023.1 (January 2023)