Literature summary for 2.3.1.241 extracted from

Hittle, L.E.; Powell, D.A.; Jones, J.W.; Tofigh, M.; Goodlett, D.R.; Moskowitz, S.M.; Ernst, R.K.
Site-specific activity of the acyltransferases HtrB1 and HtrB2 in Pseudomonas aeruginosa lipid A biosynthesis (2015), Pathog. Dis., 73, ftv053.

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Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	Q9I7B5	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	isoform HtrB1 exclusively mediates the addition of the 2-hydroxylaurate in C-2 position of lipid IVaA, while HtrB2 adds the laurate in C-2' position	Pseudomonas aeruginosa	?	-	?

Synonyms

Synonyms	Comment	Organism
HtrB1	-	Pseudomonas aeruginosa
PA0011	-	Pseudomonas aeruginosa

General Information

General Information	Comment	Organism
physiological function	a HtrB1 deletion mutant shows a decrease in 2-hydroxylaurate content in lipid A and otherwise similar growth characteristics as compared to wuild-type at all growth temperatures. A Htr2 deletion mutant shows a decrease in laurate content in lipid A and a major growth defect at 25°C and minor defects at 37 and 42°C. The htrB2 mutant shows increased susceptibility to both polymyxin B and colistin. HtrB1 and Htrb2 mutants display increased membrane permeability	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)