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Literature summary for 2.3.1.230 extracted from
- From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa (2014), Org. Biomol. Chem., 12, 6094-6104.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2-nitrophenyl)(thiophen-3-yl)methanol | inhibitor shows almost no time-dependency of PqsD inhibition | Pseudomonas aeruginosa |  |
| 1-(2-nitrophenyl)propan-1-ol | best inhibitor in the cellular test | Pseudomonas aeruginosa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | P20582 | - |
- |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0011 | - |
pH not specified in the publication, temperature not specified in the publication | Pseudomonas aeruginosa | 1-(2-nitrophenyl)propan-1-ol | |
| 0.0059 | - |
pH not specified in the publication, temperature not specified in the publication | Pseudomonas aeruginosa | (2-nitrophenyl)(thiophen-3-yl)methanol | |
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