Any feedback?
Literature summary for 2.3.1.230 extracted from
- Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD (2015), Eur. J. Med. Chem., 90, 351-359.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-(3,4-dihydroxyphenyl)-N-methylpropanamide | potent inhibitor, completely inactive in the cell-based assay | Pseudomonas aeruginosa |  |
| benzyl 3-(3,4-dihydroxyphenyl)propanoate | - |
Pseudomonas aeruginosa | |
| methyl 3-(3,4-dihydroxyphenyl)propanoate | potent inhibitor | Pseudomonas aeruginosa | |
| additional information | evaluation of selected substrates of the Medicago sativa chalcone synthase CHS2 as potential inhibitors of PqsD. Catechol derivatives possessing an ester moiety are able to reduce the production of 2-heptyl-4(1H)-quinolone in the bacterial cultures without affecting cellular growth | Pseudomonas aeruginosa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | P20582 | - |
- |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0059 | - |
pH not specified in the publication, temperature not specified in the publication | Pseudomonas aeruginosa | benzyl 3-(3,4-dihydroxyphenyl)propanoate | |
| 0.02 | - |
pH not specified in the publication, temperature not specified in the publication | Pseudomonas aeruginosa | methyl 3-(3,4-dihydroxyphenyl)propanoate | |
| 0.023 | - |
pH not specified in the publication, temperature not specified in the publication | Pseudomonas aeruginosa | 3-(3,4-dihydroxyphenyl)-N-methylpropanamide | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
