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Literature summary for 2.3.1.23 extracted from

  • Yamazaki, Y.; Yasuda, K.; Matsuyama, T.; Ishihara, T.; Higa, R.; Sawairi, T.; Yamaguchi, M.; Egi, M.; Akai, S.; Miyase, T.; Ikari, A.; Miwa, M.; Sugatani, J.
    A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice (2013), Biochem. Pharmacol., 86, 632-644.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone potent inhibitor Rattus norvegicus
3,4-dihydroxy-1,2-dimethoxy-5-methylbenzene
-
 Rattus norvegicus
3-acetoxy-2-methoxy-5-methyl-1,4-benzoquinone
-
 Rattus norvegicus
3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone potent inhibitor Rattus norvegicus
3-hexanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone
-
 Rattus norvegicus
dihydrofumigatin i.e. 2-methoxy-1,3,4- trihydroxy-5-methylbenzene Rattus norvegicus
fumigatin i.e. 3-hydroxy-2-methoxy-5-methyl-1,4-benzoquinone Rattus norvegicus
additional information not inhibited by 2-methoxy-5-methyl-1,3,4-triacetoxybenzene and 1,4-diacetoxy-2-methoxy-5-methyl-3-tetradecanoyloxybenzene Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine Rattus norvegicus
-
 CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine
-
 Rattus norvegicus CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
-
 ?

Synonyms

Synonyms Comment Organism
acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase
-
 Rattus norvegicus
lyso-PAF acetyltransferase
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.003
-
 at pH 6.9 and 37°C Rattus norvegicus 3-decanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone
0.02
-
 at pH 6.9 and 37°C Rattus norvegicus 2-methoxy-5-methyl-3-tetradecanoyloxy-1,4-benzoquinone
0.101
-
 at pH 6.9 and 37°C Rattus norvegicus dihydrofumigatin
0.109
-
 at pH 6.9 and 37°C Rattus norvegicus fumigatin
0.139
-
 at pH 6.9 and 37°C Rattus norvegicus 3-hexanoyloxy-2-methoxy-5-methyl-1,4-benzoquinone
0.166
-
 at pH 6.9 and 37°C Rattus norvegicus 3,4-dihydroxy-1,2-dimethoxy-5-methylbenzene
0.391
-
 at pH 6.9 and 37°C Rattus norvegicus 3-acetoxy-2-methoxy-5-methyl-1,4-benzoquinone

General Information

General Information Comment Organism
metabolism key enzyme in platelet-activating factor biosynthesis Rattus norvegicus