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Literature summary for 2.3.1.23 extracted from
- Lysophosphatidylcholine acyltransferase (1992), Methods Enzymol., 209, 80-86.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-acyl-sn-glycero-3-phosphocholine | - |
Oryctolagus cuniculus |  |
| 1-acyl-sn-glycero-3-phosphocholine | high concentration, lung enzyme | Rattus norvegicus | |
| Ca2+ | - |
Mammalia | |
| Clofibric acid | inhibition of mitochondrial enzyme | Rattus norvegicus | |
| Cyclic nucleotide phosphodiesterase inhibitors | gastric mucosa microsomes | Oryctolagus cuniculus | |
| Cyclic nucleotide phosphodiesterase inhibitors | liver and heart enzyme | Rattus norvegicus | |
| iodoacetate | - |
Bos taurus | |
| iodoacetate | - |
Cavia porcellus | |
| iodoacetate | - |
Mammalia | |
| iodoacetate | - |
Oryctolagus cuniculus | |
| iodoacetate | liver enzyme | Rattus norvegicus | |
| Methyllidocaine | inhibition of heart enzyme | Mammalia | |
| Mg2+ | - |
Mammalia | |
| N-ethylmaleimide | liver enzyme | Rattus norvegicus | |
| p-chloromercuriphenyl sulfonic acid | liver enzyme | Rattus norvegicus | |
| WY-14643 | inhibition of mitochondrial enzyme | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00105 | 0.0057 | acyl-CoA | saturated and unsaturated acyl donors, human platelets | Mammalia | |
| 0.0085 | - |
palmitoyl-CoA | - |
Oryctolagus cuniculus | |
| 0.061 | - |
1-acyl-sn-glycero-3-phosphocholine | - |
Oryctolagus cuniculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Cavia porcellus | 16020 | - |
| membrane | - |
Mammalia | 16020 | - |
| membrane | - |
Bos taurus | 16020 | - |
| membrane | - |
Oryctolagus cuniculus | 16020 | - |
| membrane | plasma membrane | Rattus norvegicus | 16020 | - |
| microsome | - |
Cavia porcellus | - |
- |
| microsome | - |
Mammalia | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Bos taurus | - |
- |
| microsome | - |
Oryctolagus cuniculus | - |
- |
| mitochondrion | - |
Cavia porcellus | 5739 | - |
| mitochondrion | - |
Mammalia | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
x * 43000, brain enzyme, SDS-PAGE | Bos taurus |
| 64000 | - |
x * 64000, heart enzyme, SDS-PAGE | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cavia porcellus | - |
- |
- |
| Mammalia | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1,2-diacyl-sn-glycero-3-phosphocholine | lung enzyme displays an iso-ping-pong mechanism | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| brain | - |
Oryctolagus cuniculus | - |
| gastric mucosa | - |
Oryctolagus cuniculus | - |
| liver | - |
Cavia porcellus | - |
| liver | - |
Mammalia | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| liver | - |
Oryctolagus cuniculus | - |
| lung | - |
Rattus norvegicus | - |
| lung | - |
Oryctolagus cuniculus | - |
| plasma | - |
Rattus norvegicus | - |
| smooth muscle | - |
Mammalia | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.013 | - |
acyl donor oleoyl-CoA, heart enzyme | Rattus norvegicus |
| 0.058 | - |
acyl donor oleoyl-CoA, liver enzyme | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | - |
Mammalia | CoA + 1,2-diacyl-sn-glycero-3-phosphocholine | - |
r | |
| acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | - |
Bos taurus | CoA + 1,2-diacyl-sn-glycero-3-phosphocholine | - |
r | |
| acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | - |
Oryctolagus cuniculus | CoA + 1,2-diacyl-sn-glycero-3-phosphocholine | - |
r | |
| acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | microsomal enzyme is more active toward unsaturated acyl-CoAs, the mitochondrial enzyme has a very high specificity toward linoleoyl-CoA | Cavia porcellus | CoA + 1,2-diacyl-sn-glycero-3-phosphocholine | - |
r | |
| acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | specificity for acyl-CoA with unsaturated acyl groups, 1-palmitoyl-sn-glycero-3-phosphocholine is a better acceptor than 1-stearyl-sn-glycero-3-phosphocholine | Rattus norvegicus | CoA + 1,2-diacyl-sn-glycero-3-phosphocholine | - |
r | |
| palmitoyl-CoA + 1-acyl-sn-glycero-3-phosphocholine | - |
Oryctolagus cuniculus | CoA + 1-acyl-2-palmitoyl-sn-glycero-3-phosphocholine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | - |
Cavia porcellus |
| ? | - |
Mammalia |
| ? | - |
Rattus norvegicus |
| ? | - |
Oryctolagus cuniculus |
| ? | x * 43000, brain enzyme, SDS-PAGE | Bos taurus |
| ? | x * 64000, heart enzyme, SDS-PAGE | Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Cavia porcellus |
| 25 | - |
assay at | Mammalia |
| 25 | - |
assay at | Rattus norvegicus |
| 25 | - |
assay at | Bos taurus |
| 25 | - |
assay at | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 8 | - |
Cavia porcellus |
| 7 | 8 | - |
Rattus norvegicus |
| 7 | 8 | - |
Bos taurus |
| 7 | 8 | - |
Oryctolagus cuniculus |
| 7 | 8 | value depends on acyl donor | Mammalia |
| 7 | - |
- |
Cavia porcellus |
| 7 | - |
- |
Bos taurus |
| 7 | - |
transfer of oleoyl-CoA | Rattus norvegicus |
| 7 | - |
transfer of arachidonoyl-CoA is more rapid at a higher pH, liver enzyme | Rattus norvegicus |
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Release 2023.1 (January 2023)
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