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Literature summary for 2.3.1.220 extracted from

  • Tocci, N.; Gaid, M.; Kaftan, F.; Belkheir, A.K.; Belhadj, I.; Liu, B.; Svatos, A.; Haensch, R.; Pasqua, G.; Beerhues, L.
    Exodermis and endodermis are the sites of xanthone biosynthesis in Hypericum perforatum roots (2018), New Phytol., 217, 1099-1112 .
    View publication on PubMed
Search for more literature for 2.3.1.220

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli, N-terminally His6-tagged protein Hypericum perforatum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0013
-
 benzoyl-CoA pH 7.0, 35°C Hypericum perforatum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 malonyl-CoA + benzoyl-CoA Hypericum perforatum
-
 4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Hypericum perforatum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endodermis of the root Hypericum perforatum
-
exodermis of the root Hypericum perforatum
-
root localized to the exodermis and the endodermis Hypericum perforatum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 malonyl-CoA + 3-hydroxybenzoyl-CoA 43.5% of the activity compared to benzoyl-CoA Hypericum perforatum 4 CoA + 2,3',4,6-tetrahydroxybenzophenone + 3 CO2
-
 ?
3 malonyl-CoA + benzoyl-CoA
-
 Hypericum perforatum 4 CoA + 2,4,6-trihydroxybenzophenone + 3 CO2
-
 ?
3 malonyl-CoA + butyryl-CoA formation of 36.8% 2,4,6-trihydroxybutyrophenone and 6-propyl-4-hydroxy-2-pyrone as side product Hypericum perforatum 4 CoA + 2,4,6-trihydroxybutyrophenone + 6-propyl-4-hydroxy-2-pyrone + 3 CO2
-
 ?
3 malonyl-CoA + isobutyryl-CoA formation of 46.4% 2,4,6-trihydroxyisobutyrophenone and 34.2% 6-isopropyl-4-hydroxy-2-pyrone as side product Hypericum perforatum 4 CoA + 2,4,6-trihydroxyisobutyrophenone + 3 CO2
-
 ?
additional information the enzyme does not accept 2-hydroxybenzoyl-CoA and 4-hydroxybenzoyl-CoA, acetyl-CoA, and CoA esters of cinnamic acids Hypericum perforatum ?
-
-

Synonyms

Synonyms Comment Organism
BPS
-
 Hypericum perforatum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
-
 Hypericum perforatum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0046
-
 benzoyl-CoA pH 7.0, 35°C Hypericum perforatum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
 Hypericum perforatum