Inhibitors | Comment | Organism | Structure |
---|---|---|---|
XP620 | selective isozyme DGAT1 inhibitor, inhibits the diacylglycerol acyltransferase and the retinol acyltransferase activities at the retinol recognition site | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + 1,2-diacylglycerol | Homo sapiens | - |
CoA + triacylglycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme DGAT1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + 1,2-diacylglycerol | - |
Homo sapiens | CoA + triacylglycerol | - |
? | |
additional information | isozyme DGAT1 also performs the reaction of the retinol O-fatty-acyltransferase, EC 2.3.1.76 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acyl coenzyme A:diacylglycerol acyltransferase | - |
Homo sapiens |
DGAT | - |
Homo sapiens |
DGAT1/ARAT | - |
Homo sapiens |
More | cf. EC 2.3.1.76 | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics depend highly on retinol concentration, overview, recombinant enzyme | Homo sapiens |