Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.21 extracted from

  • Yao, M.; Cai, M.; Yao, D.; Xu, X.; Yang, R.; Li, Y.; Zhang, Y.; Kido, H.; Yao, D.
    Abbreviated half-lives and impaired fuel utilization in carnitine palmitoyltransferase II variant fibroblasts (2015), PLoS ONE, 10, e0119936.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.21

Protein Variants

Protein Variants Comment Organism
F352C/V368I the mutant shows thermal instability, reduced residual enzyme activities and a short half-life compared to the wild type enzyme Homo sapiens
V368I the mutant shows thermal instability, reduced residual enzyme activities and a short half-life compared to the wild type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-carnitine Homo sapiens
-
 CoA + L-palmitoylcarnitine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P23786
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00018
-
 mutant enzyme F352C/V368I, at 30°C, pH not specified in the publication Homo sapiens
0.00027
-
 mutant enzyme V368I, at 30°C, pH not specified in the publication Homo sapiens
0.00028
-
 wild type enzyme, at 30°C, pH not specified in the publication Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 ?

Subunits

Subunits Comment Organism
homotetramer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
carnitine palmitoyltransferase II
-
 Homo sapiens
CPT II
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme deficiency leads to a significant decrease in fatty acid beta-oxidation and adenosine triphosphate generation, combined with a reduced mitochondrial membrane potential, resulting in cellular apoptosis Homo sapiens