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Literature summary for 2.3.1.21 extracted from

  • Wolfgang, M.J.; Kurama, T.; Dai, Y.; Suwa, A.; Asaumi, M.; Matsumoto, S.; Cha, S.H.; Shimokawa, T.; Lane, M.D.
    The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis (2006), Proc. Natl. Acad. Sci. USA, 103, 7282-7287.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.21

Cloned(Commentary)

Cloned (Comment) Organism
gene cpt1c, expression in HEK-293T cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information disruption of the cpt1c gene results in lower body weight and decreased food intake, construction of CPT1c knockout mice, which exhibit decreased rates of fatty acid oxidation, which may contribute to their increased susceptibility to diet-induced obesity, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
malonyl-CoA
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane
-
 Mus musculus 5741
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus CPT1c is necessary for the regulation of energy homeostasis, and does not catalyze acyl transfer from various fatty acyl-CoAs to carnitine ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 gene cpt1c, brain-specific isozyme CPT1c
-

Source Tissue

Source Tissue Comment Organism Textmining
brain brain-specific isozyme Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CPT1c is necessary for the regulation of energy homeostasis, and does not catalyze acyl transfer from various fatty acyl-CoAs to carnitine Mus musculus ?
-
 ?
additional information the brain-specific isozyme CPT1c has a unique function or activation mechanism, and does not catalyze acyl transfer from various fatty acyl-CoAs to carnitine, no activity with diverse acyl-CoAs, overview Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
carnitine palmitoyltransferase-1c
-
 Mus musculus
CPT1c
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus