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Literature summary for 2.3.1.21 extracted from

  • Jackson, V.N.; Cameron, J.M.; Fraser, F.; Zammit, V.A.; Price, N.T.
    Use of six chimeric proteins to investigate the role of intramolecular interactions in determining the kinetics of carnitine palmitoyltransferase I isoforms (2000), J. Biol. Chem., 275, 19560-19566.
    View publication on PubMed
Search for more literature for 2.3.1.21

Cloned(Commentary)

Cloned (Comment) Organism
construction of 6 chimeric proteins with exchanges structure segments of L-CPT I and M-CPT I, expression of chimeric mutants and wild-type isoforms in Pichia pastoris Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
malonyl-CoA overview: recombinant chimeric proteins of L-CPT I and M-CPT I Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information overview: Km values of recombinant chimeric proteins of L-CPT I and M-CPT I Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane
-
 Rattus norvegicus 5741
-
mitochondrion 2 isoforms of CPT I, L-CPT I and M-CPT I Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 CPT I is composed of different structural segments: 1. a cytosolic N-terminal domain of 46 amino acid residues, 2. 2 transmembranal parts TM1 and TM2, 3. a 27-residue loop between TM1 and 2, 4. a cytosolic catalytic C-terminal domain, amino acid sequences Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + L-carnitine Rattus norvegicus
-
 CoA + L-acylcarnitine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 2 isoforms L-CPT I and M-CPT I
-

Source Tissue

Source Tissue Comment Organism Textmining
liver L-CPT I Rattus norvegicus
-
liver M-CPT I Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 ?
palmitoyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-palmitoylcarnitine
-
 ?