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Literature summary for 2.3.1.21 extracted from
- Purification, characterization and partial amino acid sequences of carnitine palmitoyl-transferase from human liver (1990), FEBS Lett., 274, 163-166.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| malonyl-CoA | no inhibition | Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Km values for carnitine with different acyl-CoA substrates | Homo sapiens | |
| 0.011 | - |
lauroyl-CoA | - |
Homo sapiens | |
| 0.0122 | - |
palmitoyl-CoA | - |
Homo sapiens | |
| 0.017 | - |
decanoyl-CoA | - |
Homo sapiens | |
| 0.018 | - |
stearoyl-CoA | - |
Homo sapiens | |
| 0.023 | - |
octanoyl-CoA | - |
Homo sapiens | |
| 0.031 | - |
myristoyl-CoA | - |
Homo sapiens | |
| 0.123 | - |
L-palmitoylcarnitine | - |
Homo sapiens | |
| 0.152 | - |
hexanoyl-CoA | - |
Homo sapiens | |
| 1.139 | - |
L-octanoylcarnitine | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
amino acid sequence of peptides | Homo sapiens |
| 66000 | - |
4 * 66000, SDS-PAGE | Homo sapiens |
| 274000 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | Homo sapiens | enzyme has a key function in regulation of fatty acid beta-oxidation | CoA + L-acylcarnitine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-acylcarnitine | - |
r | |
| acyl-CoA + L-carnitine | enzyme has a key function in regulation of fatty acid beta-oxidation | Homo sapiens | CoA + L-acylcarnitine | - |
? | |
| decanoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-decanoylcarnitine | - |
r | |
| hexanoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-hexanoylcarnitine | - |
r | |
| lauroyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-lauroylcarnitine | - |
r | |
| myristoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-myristoylcarnitine | - |
r | |
| octanoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-octanoylcarnitine | - |
r | |
| palmitoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-palmitoylcarnitine | - |
r | |
| stearoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-stearoylcarnitine | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 66000, SDS-PAGE | Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Homo sapiens |
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