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Literature summary for 2.3.1.21 extracted from
- Different sites of inhibition of carnitine palmitoyltransferase by malonyl-CoA, and by acetyl-CoA and CoA, in human skeletal muscle (1987), Biochem. J., 245, 205-209.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-CoA | - |
Homo sapiens |  |
| CoA | - |
Homo sapiens | |
| malonyl-CoA | Triton X-100 protects | Homo sapiens | |
| additional information | different sites of inhibition of carnitine palmitoyltransferase by malonyl-CoA, acetyl-CoA and CoA | Homo sapiens | |
| Triton X-100 | mutant CPT | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | Homo sapiens | - |
CoA + L-acylcarnitine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skeletal muscle | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-acylcarnitine | - |
? | |
| palmitoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-palmitoylcarnitine | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00022 | - |
malonyl-CoA | - |
Homo sapiens | |
| 0.045 | - |
CoA | - |
Homo sapiens | |
| 0.045 | - |
acetyl-CoA | - |
Homo sapiens | |
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