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Literature summary for 2.3.1.206 extracted from
- PKS activities and biosynthesis of cannabinoids and flavonoids in Cannabis sativa L. plants (2008), Plant Cell Physiol., 49, 1767-1782.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | the goal for engineering of zero-cannabinoid plants is knocking out the first step of the biosynthesis catalyzed by the type III PKS enzyme | Cannabis sativa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3 malonyl-CoA + hexanoyl-CoA | Cannabis sativa | - |
3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 | formation of olivetolic acid | ? |  |
| additional information | Cannabis sativa | no formation of olivetol by an enzymatic or chemical decarboxylation from olivetolic acid, cannabinoid profiling, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cannabis sativa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bract | - |
Cannabis sativa | - |
| flower | female | Cannabis sativa | - |
| leaf | female and male | Cannabis sativa | - |
| additional information | no enzyme activity in seedlings, fruits, and roots. Neither cannabinoid acids nor their decarboxylated forms are found in seedlings and roots in the four varieties of cannabis plants. Accumulation of cannabinoids in bracts during the growth and development of glandular trichomes from flowers | Cannabis sativa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0024 | - |
highest tissue activity, in bracts, pH 7.0, 30°C | Cannabis sativa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3 malonyl-CoA + hexanoyl-CoA | - |
Cannabis sativa | 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 | formation of olivetolic acid | ? | |
| additional information | no formation of olivetol by an enzymatic or chemical decarboxylation from olivetolic acid, cannabinoid profiling, overview | Cannabis sativa | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| olivetol synthase | - |
Cannabis sativa |
| olivetol-forming PKS | - |
Cannabis sativa |
| PKS | - |
Cannabis sativa |
| type III PKS | - |
Cannabis sativa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Cannabis sativa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Cannabis sativa |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is involved the biosynthesis of the first precursor of cannabinoids, olivetolic acid. Cannabinoid and flavonoid profiling, overview. Accumulation of cannabinoids in bracts during the growth and development of glandular trichomes from flowers, cannabinoid accumulation iscorrelated with maximum activities for an olivetol-forming PKS, developmental and defens-related regulation of cannabinoid pathway enzymes, overview | Cannabis sativa |
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