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Literature summary for 2.3.1.20 extracted from

  • Kaylor, J.J.; Radu, R.A.; Bischoff, N.; Makshanoff, J.; Hu, J.; Lloyd, M.; Eddington, S.; Bianconi, T.; Bok, D.; Travis, G.H.
    Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium (2015), PLoS ONE, 10, e0125921.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0085
-
11-cis-retinol at pH 8.0 and 37°C Mus musculus
0.0099
-
all-trans-retinol at pH 8.0 and 37°C Mus musculus
0.0188
-
13-cis-retinol at pH 8.0 and 37°C Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
x * 45000, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Mueller glial cell
-
Mus musculus
-
retina
-
Mus musculus
-
retinal pigment epithelium cell
-
Mus musculus
-
RPE cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + 11-cis-retinol
-
Mus musculus ?
-
?
palmitoyl-CoA + 13-cis-retinol
-
Mus musculus ?
-
?
palmitoyl-CoA + all-trans-retinol
-
Mus musculus ?
-
?

Subunits

Subunits Comment Organism
? x * 45000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
DGAT1
-
Mus musculus
diacylglycerol O-acyltransferase type-1
-
Mus musculus
diacylglycerol O-acyltransferase-1
-
Mus musculus

General Information

General Information Comment Organism
malfunction enzyme-deficient mice show no effect on retinal anatomy or the ultrastructure of photoreceptor outer-segments. Enzyme loss affects retinyl-ester synthesis and total acyl-coenzyme A:retinol acyl-transferase activityin the eye Mus musculus