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Literature summary for 2.3.1.20 extracted from

  • Seo, J.H.; Kim, M.O.; Han, A.R.; Kwon, E.B.; Kang, M.J.; Cho, S.; Moon, D.O.; Noh, J.R.; Lee, C.H.; Kim, Y.S.; Lee, H.S.
    Oleanane-type triterpenoids of Aceriphyllum rossii and their diacylglycerol acyltransferase-inhibitory activity (2015), Planta Med., 81, 228-234.
    View publication on PubMed
Search for more literature for 2.3.1.20

Inhibitors

Inhibitors Comment Organism Structure
3-oxoolean-12-en-27-oic acid the compound exhibits strong inhibition efficacy towards diacylglycerol acyltransferases 1 and 2, and acts competitively against oleoyl-CoA in vitro Homo sapiens
3alpha-hydroxyolean-12-en-27-oic acid
-
 Homo sapiens
3beta-hydroxyolean-12-en-27-oic acid
-
 Homo sapiens
aceriphyllic acid A the compound exhibits strong inhibition efficacy towards diacylglycerol acyltransferases 1 and 2, and acts competitively against oleoyl-CoA in vitro Homo sapiens
gypsogenic acid
-
 Homo sapiens
oleanolic acid
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + 1,2-diacyl-sn-glycerol Homo sapiens
-
 CoA + triacylglycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
HuTu-80 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + 1,2-diacyl-sn-glycerol
-
 Homo sapiens CoA + triacylglycerol
-
 ?

Synonyms

Synonyms Comment Organism
DGAT1 isoform Homo sapiens
DGAT2 isoform Homo sapiens
diacylglycerol acyltransferase
-
 Homo sapiens