Cloned (Comment) | Organism |
---|---|
short-term hepatic overexpression of DGAT1 in mice using adenoviral vectors results in 2.0fold increases in the triglyceride content of liver, the increase in hepatic triglyceride content has no effect on the production rate of VLDL triglyceride or apoB | Mus musculus |
short-term hepatic overexpression of DGAT2 in mice using adenoviral vectors results in 2.4fold increases in the triglyceride content of liver, the increase in hepatic triglyceride content has no effect on the production rate of VLDL triglyceride or apoB | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | short-term overexpression of DGAT1 increases hepatic triglyceride but not VLDL triglyceride or apoB production, overview | Mus musculus |
additional information | short-term overexpression of DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
x * 45000, recombinant DGAT2, SDS-PAGE | Mus musculus |
47000 | - |
x * 47000, recombinant DGAT1, SDS-PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | increasing the cytoplasmic triglyceride pool in hepatocytes does not directly influence VLDL triglyceride or apoB production, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9DCV3 | gene DGAT2; gene DGAT2 | - |
Mus musculus | Q9Z2A7 | gene DGAT1; gene DGAT1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
plasma and liver lipid levels of wild-type mice compared to recombinant DGAT1 overexpressing mice | Mus musculus |
additional information | - |
plasma and liver lipid levels of wild-type mice compared to recombinant DGAT2 overexpressing mice | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | increasing the cytoplasmic triglyceride pool in hepatocytes does not directly influence VLDL triglyceride or apoB production, overview | Mus musculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 45000, recombinant DGAT2, SDS-PAGE | Mus musculus |
? | x * 47000, recombinant DGAT1, SDS-PAGE | Mus musculus |