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Literature summary for 2.3.1.20 extracted from

  • Meegalla, R.L.; Billheimer, J.T.; Cheng, D.
    Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin (2002), Biochem. Biophys. Res. Commun., 298, 317-323.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
glucose treatment of adipocytes with glucose increases DGAT1 mRNA Mus musculus
Insulin treatment of adipocytes with insulin increases DGAT2 mRNA Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + 1,2-diacylglycerol Mus musculus DGAT1 is more involved in fat absorption in the intestine and DGAT2 plays important role in assembly of de novo synthesized fatty acids into VLDL particles in liver CoA + triacylglycerol
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell 3T3-L1 fibroblasts differentiated into adipocytes Mus musculus
-
adipocyte
-
Mus musculus
-
liver
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0003
-
membrane fraction after insulin-starvation Mus musculus
0.00036
-
membrane fraction after carbohydrate-starvation Mus musculus
0.00265
-
membrane fraction Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + 1,2-diacylglycerol DGAT1 is more involved in fat absorption in the intestine and DGAT2 plays important role in assembly of de novo synthesized fatty acids into VLDL particles in liver Mus musculus CoA + triacylglycerol
-
?