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Literature summary for 2.3.1.20 extracted from
- Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells [published erratum appears in J Biol Chem 1988 Jul 25;263(21):10539] (1988), J. Biol. Chem., 263, 2593-2596.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-O-Hexadecyl-2-oleoyl-sn-glycerol | competitive | Homo sapiens |  |
| DTT | above 2 mM | Homo sapiens | |
| MgCl2 | 20 mM | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | 1.4fold stimulation | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HL-60 cell | leukemia, HL-60 cell line | Homo sapiens | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 30 days, microsomal preparation | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + 1,2-diacylglycerol | - |
Homo sapiens | CoA + triacylglycerol | - |
? | |
| linoleoyl-CoA + 1,2-diacylglycerol | - |
Homo sapiens | CoA + 1,2-diacyl-3-linoleoylglycerol | - |
? | |
| myristoyl-CoA + 1,2-diacylglycerol | - |
Homo sapiens | CoA + 1,2-diacyl-3-myristoylglycerol | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay at various temperatures from 24°C to 40°C | Homo sapiens |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
labile above, gradual inactivation | Homo sapiens |
| 40 | - |
20% loss of activity after 15 min | Homo sapiens |
| 50 | - |
t1/2: 15 min | Homo sapiens |
| 65 | - |
inactivation after 15 min | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.1 | - |
broad | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.032 | - |
1-O-Hexadecyl-2-oleoyl-sn-glycerol | - |
Homo sapiens | |
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