BRENDA - Enzyme Database show
show all sequences of 2.3.1.192

Interaction of 2,4-dichlorophenoxyacetate (2,4-D) and 2,4,5-trichlorophenoxyacetate (2,4,5-T) with the acyl-CoA: amino acid N-acyltransferase enzymes of bovine liver mitochondria

Kelley, M.; Vessey, D.A.; Biochem. Pharmacol. 35, 289-295 (1986)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
2,4,5-trichlorophenoxyacetyl-CoA
competitive
Bos taurus
2,4-dichlorophenoxyacetyl-CoA
competitive
Bos taurus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
9
-
glycine
cosubstrate phenylacetyl-CoA, pH 8.0, 30°C
Bos taurus
1000
-
glycine
cosubstrate 2,4-dichlorophenoxyacetyl-CoA pH 8.0, 30°C
Bos taurus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Bos taurus
5739
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Bos taurus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2,4-dichlorophenoxyacetyl-CoA + glycine
-
707446
Bos taurus
2,4-dichlorophenoxyacetylglycine + CoA
-
-
-
?
additional information
no substrate: 2,4,5-trichlorophenoxyacetyl-CoA
707446
Bos taurus
?
-
-
-
-
phenoxyacetyl-CoA + glycine
overall rate of conjugation of the phenoxyherbicides are slow relative to the standard substrate phenylacetyl-CoA
707446
Bos taurus
phenoxyacetylglycine + CoA
-
-
-
?
phenylacetyl-CoA + glycine
-
707446
Bos taurus
phenylacetylglycine + CoA
-
-
-
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2,4,5-trichlorophenoxyacetyl-CoA
competitive
Bos taurus
2,4-dichlorophenoxyacetyl-CoA
competitive
Bos taurus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
9
-
glycine
cosubstrate phenylacetyl-CoA, pH 8.0, 30°C
Bos taurus
1000
-
glycine
cosubstrate 2,4-dichlorophenoxyacetyl-CoA pH 8.0, 30°C
Bos taurus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Bos taurus
5739
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2,4-dichlorophenoxyacetyl-CoA + glycine
-
707446
Bos taurus
2,4-dichlorophenoxyacetylglycine + CoA
-
-
-
?
additional information
no substrate: 2,4,5-trichlorophenoxyacetyl-CoA
707446
Bos taurus
?
-
-
-
-
phenoxyacetyl-CoA + glycine
overall rate of conjugation of the phenoxyherbicides are slow relative to the standard substrate phenylacetyl-CoA
707446
Bos taurus
phenoxyacetylglycine + CoA
-
-
-
?
phenylacetyl-CoA + glycine
-
707446
Bos taurus
phenylacetylglycine + CoA
-
-
-
?
Other publictions for EC 2.3.1.192
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
708944
Vessey
Determination of the sequence ...
Bos taurus
J. Biochem. Mol. Toxicol.
12
275-279
1998
-
-
1
-
-
-
-
-
2
-
1
-
-
2
-
1
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
487441
Kelley
Characterization of the acyl-C ...
Homo sapiens
J. Biochem. Toxicol.
9
153-158
1994
-
-
-
-
-
-
2
1
1
-
-
-
-
1
-
-
1
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
1
-
-
-
-
-
-
1
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
487438
Kelley
The effects of ions on the con ...
Bos taurus
J. Biochem. Toxicol.
5
125-135
1990
2
-
-
-
-
-
5
-
1
3
2
-
-
1
-
-
1
-
-
1
1
-
5
1
-
-
-
-
-
-
-
-
-
1
1
2
-
-
-
-
-
-
1
5
-
-
1
3
2
-
-
-
-
1
-
1
1
-
5
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
707446
Kelley
Interaction of 2,4-dichlorophe ...
Bos taurus
Biochem. Pharmacol.
35
289-295
1986
-
-
-
-
-
-
2
2
1
-
-
-
-
3
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
1
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486265
Nandi
Benzoyl-coenzyme A:glycine N-a ...
Bos taurus
J. Biol. Chem.
254
7230-7237
1979
-
-
-
-
-
-
8
-
-
1
1
-
-
2
-
-
1
1
-
1
1
-
4
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
1
1
-
-
-
-
1
-
1
1
-
4
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-