BRENDA - Enzyme Database show
show all sequences of 2.3.1.191

Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli

Li, C.; Guan, Z.; Liu, D.; Raetz, C.R.; Proc. Natl. Acad. Sci. USA 108, 11387-11392 (2011)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene AtlpxD, two AtLpxD isozymes, AtLxpD1 and AtLpxD2, are encoded on chromosome 4, DNA and amino acid sequence determination and analysis, expression as GFP-tagged protein in Arabidopsis thaliana
Arabidopsis thaliana
Engineering
Amino acid exchange
Commentary
Organism
additional information
construction of lpx insertional knockout mutations or RNAi knock-down mutants
Arabidopsis thaliana
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
LpxD proteins in Arabidopsis thaliana are targeted to the mitochondria, subcellular localization analysis, overview
Arabidopsis thaliana
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(3R)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine
Arabidopsis thaliana
-
UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein]
-
-
ir
(3R)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine
Arabidopsis thaliana Col-0
-
UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein]
-
-
ir
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Arabidopsis thaliana
F4JGP6
AtlpxD1; gene AtlpxD1
-
Arabidopsis thaliana Col-0
F4JGP6
AtlpxD1; gene AtlpxD1
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(3R)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine
-
720913
Arabidopsis thaliana
UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein]
-
-
-
ir
(3R)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine
-
720913
Arabidopsis thaliana Col-0
UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein]
-
-
-
ir
Cloned(Commentary) (protein specific)
Commentary
Organism
gene AtlpxD, two AtLpxD isozymes, AtLxpD1 and AtLpxD2, are encoded on chromosome 4, DNA and amino acid sequence determination and analysis, expression as GFP-tagged protein in Arabidopsis thaliana
Arabidopsis thaliana
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
construction of lpx insertional knockout mutations or RNAi knock-down mutants
Arabidopsis thaliana
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
LpxD proteins in Arabidopsis thaliana are targeted to the mitochondria, subcellular localization analysis, overview
Arabidopsis thaliana
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
(3R)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine
Arabidopsis thaliana
-
UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein]
-
-
ir
(3R)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine
Arabidopsis thaliana Col-0
-
UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein]
-
-
ir
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(3R)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine
-
720913
Arabidopsis thaliana
UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein]
-
-
-
ir
(3R)-3-hydroxymyristoyl-[acyl-carrier protein] + UDP-3-O-[(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine
-
720913
Arabidopsis thaliana Col-0
UDP-2,3-bis[O-(3R)-3-hydroxymyristoyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein]
-
-
-
ir
General Information
General Information
Commentary
Organism
metabolism
the enzyme is involved in the lipid A biosynthesis in the plant
Arabidopsis thaliana
General Information (protein specific)
General Information
Commentary
Organism
metabolism
the enzyme is involved in the lipid A biosynthesis in the plant
Arabidopsis thaliana
Other publictions for EC 2.3.1.191
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735568
Alshalchi
Expression of the lipopolysacc ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa UCBPP-PA14
Arch. Microbiol.
197
135-145
2015
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1
1
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736235
Eshghi
Leptospira interrogans lpxD ho ...
Leptospira interrogans, Leptospira interrogans L495
Infect. Immun.
83
4314-4321
2015
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8
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1
1
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736449
Jenkins
Structural basis for the recog ...
Escherichia coli
J. Biol. Chem.
289
15527-15535
2014
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1
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736880
Masoudi
Chasing acyl carrier protein t ...
Escherichia coli
Nature
505
422-426
2014
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1
1
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1
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1
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737072
Emiola
A complete pathway model for l ...
Escherichia coli
PLoS ONE
10
e0121216
2014
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1
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1
1
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735384
Badger
Structure determination of Lpx ...
Acinetobacter baumannii, Acinetobacter baumannii SDF
Acta Crystallogr. Sect. F
69
6-9
2013
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1
1
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2
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736185
Yeom
Pleiotropic effects of acyltra ...
Pseudomonas aeruginosa
Genes Cells
18
682-693
2013
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2
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1
1
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718571
Jenkins
A continuous fluorescent enzym ...
Escherichia coli
Anal. Biochem.
425
21-27
2012
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1
1
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2
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720944
Li
LPS remodeling is an evolved s ...
Francisella tularensis subsp. novicida, Francisella tularensis subsp. novicida U112
Proc. Natl. Acad. Sci. USA
109
8716-8721
2012
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1
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1
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7
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4
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4
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3
3
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718513
Badger
The structure of LpxD from Pse ...
Pseudomonas aeruginosa
Acta Crystallogr. Sect. F
67
749-752
2011
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1
1
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720913
Li
Pathway for lipid A biosynthes ...
Arabidopsis thaliana, Arabidopsis thaliana Col-0
Proc. Natl. Acad. Sci. USA
108
11387-11392
2011
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1
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1
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1
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2
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1
1
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696356
Bartling
Crystal structure and acyl cha ...
Escherichia coli
Biochemistry
48
8672-8683
2009
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1
1
2
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3
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696264
Bartling
Steady-state kinetics and mech ...
Escherichia coli
Biochemistry
47
5290-5302
2008
1
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1
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10
-
8
21
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3
1
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1
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1
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2
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3
1
1
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23
1
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7
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2
1
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1
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10
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2
8
7
21
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3
1
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1
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2
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3
1
1
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23
1
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11
11
698587
Bainbridge
Acyl chain specificity of the ...
Escherichia coli, Porphyromonas gingivalis
J. Bacteriol.
190
4549-4558
2008
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2
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2
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694027
Albers
Expression of Legionella pneum ...
Legionella pneumophila
Microbiology
153
3817-3829
2007
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6
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700935
Buetow
Structure and reactivity of Lp ...
Chlamydia trachomatis
Proc. Natl. Acad. Sci. USA
104
4321-4326
2007
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1
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695627
Vaara
Outer membrane permeability ba ...
Escherichia coli
Antimicrob. Agents Chemother.
43
1459-1462
1999
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698088
Steeghs
Isolation and characterization ...
Neisseria meningitidis
Gene
190
263-270
1997
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1
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697921
Vuorio
The novel hexapeptide motif fo ...
Yersinia enterocolitica
FEBS Lett.
337
289-292
1994
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698693
Kelly
Raetz, C.R.; Anderson, M.S.: T ...
Escherichia coli
J. Biol. Chem.
268
19866-19874
1993
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