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Literature summary for 2.3.1.187 extracted from
- Enzymic and genetic basis for bacterial growth on malonate (1997), Mol. Microbiol., 25, 3-10.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene mdcA, encoded in the malonate decarboxylase operon mdc, genetic organization | Klebsiella pneumoniae |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60800 | - |
x * 60800, isolated acetyl-S-ACP:malonate ACP transferase C-terminal alpha subunit of the malonate decarboxylase complex, SDS-PAGE | Klebsiella pneumoniae |
| 61200 | - |
x * 61200, isolated acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase moiety of the enzyme complex, SDS-PAGE | Malonomonas rubra |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| malonate + acetyl-[acyl-carrier protein] | Klebsiella pneumoniae | - |
acetate + malonyl-[acyl-carrier protein] | - |
? |  |
| malonate + acetyl-[acyl-carrier protein] | Malonomonas rubra | - |
acetate + malonyl-[acyl-carrier protein] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Klebsiella pneumoniae | - |
gene mdcA, encoded in the malonate decarboxylase operon mdc | - |
| Malonomonas rubra | - |
gene madA, encoded in the malonate decarboxylase operon mad | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| isolated soluble native transferase component of the malonate decarboxylase | Malonomonas rubra |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| malonate + acetyl-[acyl-carrier protein] | - |
Klebsiella pneumoniae | acetate + malonyl-[acyl-carrier protein] | - |
? | |
| malonate + acetyl-[acyl-carrier protein] | - |
Malonomonas rubra | acetate + malonyl-[acyl-carrier protein] | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 60800, isolated acetyl-S-ACP:malonate ACP transferase C-terminal alpha subunit of the malonate decarboxylase complex, SDS-PAGE | Klebsiella pneumoniae |
| ? | x * 61200, isolated acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase moiety of the enzyme complex, SDS-PAGE | Malonomonas rubra |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acetyl-S-ACP:malonate ACP transferase | - |
Klebsiella pneumoniae |
| acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase | - |
Malonomonas rubra |
| MadA | - |
Malonomonas rubra |
| MdcA | - |
Klebsiella pneumoniae |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | to achieve decarboxylation of malonate, the key reaction in the decomposition of this compound, the substrate must be activated by the malonate decarboxylase to a malonyl thio-enzyme ester involving an activation module that comprises the acetylation of a specific thiol group of an acyl carrier protein, ACP, and the transfer of the ACP moiety to malonate, yielding malonyl-S-ACP and acetate. The malonyl-S-ACP is subsequently decarboxylated with regeneration of the acetyl-ACP. Malonate decarboxylation pathway, overview | Klebsiella pneumoniae |
| metabolism | to achieve decarboxylation of malonate, the key reaction in the decomposition of this compound, the substrate must be activated by the malonate decarboxylase to a malonyl thio-enzyme ester involving an activation module that comprises the acetylation of a specific thiol group of an acyl carrier protein, ACP, and the transfer of the ACP moiety to malonate, yielding malonyl-S-ACP and acetate. The malonyl-S-ACP is subsequently decarboxylated with regeneration of the acetyl-ACP. Malonate decarboxylation pathway, overview | Malonomonas rubra |
| additional information | the acetyl-S-ACP:malonate ACP transferase is a component of the malonate decarboxylase complex | Klebsiella pneumoniae |
| additional information | the acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase is a component of the malonate decarboxylase complex | Malonomonas rubra |
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