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Literature summary for 2.3.1.180 extracted from

  • Lv, P.C.; Sun, J.; Luo, Y.; Yang, Y.; Zhu, H.L.
    Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors (2010), Bioorg. Med. Chem. Lett., 20, 4657-4660.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-[3,5-bis(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
Escherichia coli
1-[3-(4-methoxyphenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
Escherichia coli
1-[3-(4-methoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
Escherichia coli
1-[5-(2-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
Escherichia coli
1-[5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
Escherichia coli
1-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
Escherichia coli
1-[5-(4-fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Synonyms

Synonyms Comment Organism
beta-ketoacyl-acyl carrier protein synthase III
-
Escherichia coli
FabH
-
Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0042
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli 1-[5-(4-fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
0.0076
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli 1-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
0.0104
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli 1-[5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
0.0173
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli 1-[3-(4-methoxyphenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
0.0196
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli 1-[3,5-bis(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
0.0314
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli 1-[5-(2-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone
0.0467
-
pH not specified in the publication, temperature not specified in the publication Escherichia coli 1-[3-(4-methoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone