Cloned (Comment) | Organism |
---|---|
gene fabH, overexpression of N-terminally His6-tagged FabH in Escherichia coli strain BL21(DE3) | Francisella tularensis subsp. holarctica |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(2,6-dichlorobenzyl)-5-[(3-methoxybenzyl)oxy]-1H-indole-2-carboxylic acid | - |
Francisella tularensis subsp. holarctica | |
1-(2,6-dichlorobenzyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid | - |
Francisella tularensis subsp. holarctica | |
1-(2,6-dichlorobenzyl)-5-[[4-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid | an indole derivative, inhibits FabH by 98% at 0.0375 mM | Francisella tularensis subsp. holarctica | |
1-(2-bromobenzyl)-5-[(3-methoxybenzyl)oxy]-1H-indole-2-carboxylic acid | - |
Francisella tularensis subsp. holarctica | |
1-(4-carboxybenzyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid | an indole derivative, inhibits FabH by 80% at 0.040 mM | Francisella tularensis subsp. holarctica | |
1-(5-carboxypentyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid | - |
Francisella tularensis subsp. holarctica | |
1-[4-(trifluoromethyl)benzyl]-5-[[4-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid | - |
Francisella tularensis subsp. holarctica | |
5-[(2,6-dichlorobenzyl)oxy]-1-(4-methoxybenzyl)-1H-indole-2-carboxylic acid | - |
Francisella tularensis subsp. holarctica | |
5-[(2,6-dichlorobenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid | an indole derivative, inhibits FabH by 98% at 0.0375 mM | Francisella tularensis subsp. holarctica | |
5-[(2-bromobenzyl)oxy]-1-(4-methoxybenzyl)-1H-indole-2-carboxylic acid | - |
Francisella tularensis subsp. holarctica | |
5-[(2-bromobenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid | an indole derivative, inhibits FabH by 80% at 0.040 mM | Francisella tularensis subsp. holarctica | |
5-[(4-methoxybenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid | - |
Francisella tularensis subsp. holarctica | |
5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid | - |
Francisella tularensis subsp. holarctica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-[acyl-carrier protein] | Francisella tularensis subsp. holarctica | - |
3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Francisella tularensis subsp. holarctica | A0SPA8 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant N-terminally His6-tagged FabH from Escherichia coli strain BL21(DE3) by nickel affinity chromatography | Francisella tularensis subsp. holarctica |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-[acyl-carrier protein] | - |
Francisella tularensis subsp. holarctica | 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-oxoacyl-acyl carrier protein synthase III | - |
Francisella tularensis subsp. holarctica |
FabH | - |
Francisella tularensis subsp. holarctica |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Francisella tularensis subsp. holarctica |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Francisella tularensis subsp. holarctica |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.002 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 5-[(2-bromobenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid | |
0.004 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 1-(2,6-dichlorobenzyl)-5-[[4-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid | |
0.006 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 1-(2,6-dichlorobenzyl)-5-[(3-methoxybenzyl)oxy]-1H-indole-2-carboxylic acid | |
0.006 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 5-[(2,6-dichlorobenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid | |
0.007 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 1-[4-(trifluoromethyl)benzyl]-5-[[4-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid | |
0.015 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 1-(2,6-dichlorobenzyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid | |
0.015 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid | |
0.017 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 5-[(2-bromobenzyl)oxy]-1-(4-methoxybenzyl)-1H-indole-2-carboxylic acid | |
0.017 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 5-[(2,6-dichlorobenzyl)oxy]-1-(4-methoxybenzyl)-1H-indole-2-carboxylic acid | |
0.017 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 1-(2-bromobenzyl)-5-[(3-methoxybenzyl)oxy]-1H-indole-2-carboxylic acid | |
0.02 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 5-[(4-methoxybenzyl)oxy]-1-[4-(trifluoromethyl)benzyl]-1H-indole-2-carboxylic acid | |
0.026 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 1-(2,6-dichlorobenzyl)-5-[(3-methoxybenzyl)oxy]-1H-indole-2-carboxylic acid | |
0.036 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 1-[4-(trifluoromethyl)benzyl]-5-[[4-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid | |
0.04 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 1-(4-carboxybenzyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid | |
0.042 | - |
pH 7.0, 37°C | Francisella tularensis subsp. holarctica | 1-(5-carboxypentyl)-5-[[2-fluoro-6-(trifluoromethyl)benzyl]oxy]-1H-indole-2-carboxylic acid |
General Information | Comment | Organism |
---|---|---|
physiological function | FabH initiates elongation in fatty acid synthesis FAS-II, type II fatty acid biosynthesis pathway overview | Francisella tularensis subsp. holarctica |